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rdf:type |
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lifeskim:mentions |
umls-concept:C0001963,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0206190,
umls-concept:C0806909,
umls-concept:C1187759,
umls-concept:C1515999,
umls-concept:C1555707,
umls-concept:C1705851,
umls-concept:C1948023,
umls-concept:C2752151,
umls-concept:C2828366
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pubmed:issue |
4
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pubmed:dateCreated |
2008-11-21
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pubmed:abstractText |
Sedum telephium ssp. maximum is a medicinal plant that possesses anti-inflammatory, analgesic and keratolytic properties. We investigated the anti-inflammatory activity of its methanolic extract (STME) in rat peritoneal macrophages (MPhis) stimulated with lipopolysaccharide from Salmonella enteritidis. After stimulation with 10 microg/ml of LPS, MPhis were coincubated with different doses of STME (8, 16 and 32 microg/ml) or RPMI medium alone using different times of incubation. STME reduced levels of tumor necrosis factor-alpha, both mRNA and its protein, and significantly decreased IL-1beta and IL-6 production. Moreover, STME inhibited inducible nitric oxide synthase expression and blunted nitrite release and inhibited both extracellular signal-regulated kinase 1/2 and c-Jun N-terminal kinase activation in lipopolysaccharide-stimulated MPhis. Data show that STME might be useful as a potential anti-inflammatory agent.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1beta,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:issn |
1423-0313
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pubmed:author |
pubmed-author:AltavillaDomenicaD,
pubmed-author:BiagiMarcoM,
pubmed-author:BittoAlessandraA,
pubmed-author:FiumaraTizianaT,
pubmed-author:GiachettiDanielaD,
pubmed-author:MariniHerbertH,
pubmed-author:MinutoliLetteriaL,
pubmed-author:MiraldiElisabettaE,
pubmed-author:PolitoFrancescaF,
pubmed-author:SquadritoFrancescoF,
pubmed-author:VaccaroMarioM
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pubmed:copyrightInfo |
Copyright 2008 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
250-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18818510-Animals,
pubmed-meshheading:18818510-Anti-Inflammatory Agents,
pubmed-meshheading:18818510-Dose-Response Relationship, Drug,
pubmed-meshheading:18818510-Gene Expression Regulation,
pubmed-meshheading:18818510-Inflammation,
pubmed-meshheading:18818510-Interleukin-1beta,
pubmed-meshheading:18818510-Interleukin-6,
pubmed-meshheading:18818510-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:18818510-Lipopolysaccharides,
pubmed-meshheading:18818510-Macrophages, Peritoneal,
pubmed-meshheading:18818510-Male,
pubmed-meshheading:18818510-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:18818510-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:18818510-Nitric Oxide Synthase Type II,
pubmed-meshheading:18818510-Plant Extracts,
pubmed-meshheading:18818510-RNA, Messenger,
pubmed-meshheading:18818510-Rats,
pubmed-meshheading:18818510-Rats, Sprague-Dawley,
pubmed-meshheading:18818510-Salmonella enteritidis,
pubmed-meshheading:18818510-Sedum,
pubmed-meshheading:18818510-Tumor Necrosis Factor-alpha
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pubmed:year |
2008
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pubmed:articleTitle |
Anti-inflammatory effects of the methanol extract of Sedum telephium ssp. maximum in lipopolysaccharide- stimulated rat peritoneal macrophages.
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pubmed:affiliation |
Section of Pharmaceutical Biology, Department of Environmental Science, University of Siena, Siena, Italy.
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pubmed:publicationType |
Journal Article
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