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rdf:type |
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lifeskim:mentions |
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0205225,
umls-concept:C0332197,
umls-concept:C0449297,
umls-concept:C0949536,
umls-concept:C1332714,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1552861,
umls-concept:C1706438,
umls-concept:C2698600
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pubmed:issue |
23
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pubmed:dateCreated |
2008-11-12
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pubmed:abstractText |
CD4 T cells are dispensable for acute control of murine gammaherpesvirus 68 (MHV-68) but are necessary for effective long-term control of the virus by CD8 T cells. In contrast, protein kinase C theta (PKCtheta) is not essential for either acute or long-term viral control. However, we found that while either CD4 or CD8 T cells could mediate the clearance of MHV-68 from the lungs of PKCtheta(+/+) mice, PKCtheta(-/-) mice depleted of either subset failed to clear the virus. These data suggest that there are two alternative pathways for MHV-68 clearance, one dependent on CD4 T cells and the other on PKCtheta. Protection mediated by the latter appears to be short-lived. These observations may help to explain the differential requirement for PKCtheta in various models of CD8 T-cell activation and differences in the costimulatory requirements for acute and long-term viral control.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-10073710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-10074181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-10220431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-10229071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-10395681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-10746729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-10878386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-11353832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-11376344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-11395389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-11458005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-11861872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-11973130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-12782715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-1328491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-1469366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-15024044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-15263025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-15890920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-16186501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-17404306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-18768977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-2161903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-2351958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-6111210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-7925438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-8394447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-8444877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-8460488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-8627809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-8922476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-8985252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-9064346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-9094668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-9223479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-9396604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-9617893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18818318-9625754
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1098-5514
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11970-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18818318-Animals,
pubmed-meshheading:18818318-CD4-Positive T-Lymphocytes,
pubmed-meshheading:18818318-CD8-Positive T-Lymphocytes,
pubmed-meshheading:18818318-Cell Movement,
pubmed-meshheading:18818318-Cytotoxicity, Immunologic,
pubmed-meshheading:18818318-Interferon-gamma,
pubmed-meshheading:18818318-Isoenzymes,
pubmed-meshheading:18818318-Lung,
pubmed-meshheading:18818318-Mice,
pubmed-meshheading:18818318-Protein Kinase C,
pubmed-meshheading:18818318-Rhadinovirus
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pubmed:year |
2008
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pubmed:articleTitle |
Primary clearance of murine gammaherpesvirus 68 by PKCtheta-/- CD8 T cells is compromised in the absence of help from CD4 T cells.
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pubmed:affiliation |
Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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