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pubmed-article:18817889pubmed:abstractTextReverse proteolysis and transpeptidation lead to the generation of polypeptide sequences that cannot be inferred directly from genome sequences as they are post-translational phenomena. These phenomena have so far received little attention although the physiological consequences may reach far. The protease-mediated synthesis of several immunodominant MHC class I antigens was recently reported, underscoring its importance to immunity. Reverse proteolytic and transpeptidation mechanisms as well as conditions that favor successful protease-catalyzed synthetic events are discussed here.lld:pubmed
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pubmed-article:18817889pubmed:articleTitleTranspeptidation and reverse proteolysis and their consequences for immunity.lld:pubmed
pubmed-article:18817889pubmed:affiliationDivision of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.lld:pubmed
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