Source:http://linkedlifedata.com/resource/pubmed/id/18817889
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2008-11-21
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pubmed:abstractText |
Reverse proteolysis and transpeptidation lead to the generation of polypeptide sequences that cannot be inferred directly from genome sequences as they are post-translational phenomena. These phenomena have so far received little attention although the physiological consequences may reach far. The protease-mediated synthesis of several immunodominant MHC class I antigens was recently reported, underscoring its importance to immunity. Reverse proteolytic and transpeptidation mechanisms as well as conditions that favor successful protease-catalyzed synthetic events are discussed here.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1357-2725
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
66-71
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pubmed:meshHeading |
pubmed-meshheading:18817889-Animals,
pubmed-meshheading:18817889-Antigen Presentation,
pubmed-meshheading:18817889-Catalysis,
pubmed-meshheading:18817889-Endopeptidases,
pubmed-meshheading:18817889-Histocompatibility Antigens Class I,
pubmed-meshheading:18817889-Humans,
pubmed-meshheading:18817889-Immunity,
pubmed-meshheading:18817889-Models, Biological,
pubmed-meshheading:18817889-Peptides,
pubmed-meshheading:18817889-Protein Processing, Post-Translational
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pubmed:year |
2009
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pubmed:articleTitle |
Transpeptidation and reverse proteolysis and their consequences for immunity.
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pubmed:affiliation |
Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Review
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