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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2008-10-20
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pubmed:abstractText |
The emergence and spread of Plasmodium falciparum resistance to almost all available antimalarial drugs necessitates the search for new chemotherapeutic compounds. The ubiquitin/proteasome system plays a major role in overall protein turnover, especially in fast dividing eukaryotic cells including plasmodia. Previous studies show that the 20S proteasome is expressed and catalytically active in plasmodia and treatment with proteasome inhibitors arrests parasite growth. This is the first comprehensive screening of proteasome inhibitors with different chemical modes of action against laboratory strains of P. falciparum. Subsequently, a selection of inhibitors was tested in field isolates from Lambaréné, Gabon.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18816382-10468620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18816382-10508680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18816382-10574782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18816382-11239469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18816382-11564559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18816382-12019072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18816382-12873125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18816382-15659509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18816382-16038394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18816382-16384554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18816382-16616382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18816382-16861477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18816382-17172389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18816382-9756786
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1475-2875
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
187
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18816382-Adolescent,
pubmed-meshheading:18816382-Animals,
pubmed-meshheading:18816382-Antimalarials,
pubmed-meshheading:18816382-Artemisinins,
pubmed-meshheading:18816382-Child,
pubmed-meshheading:18816382-Child, Preschool,
pubmed-meshheading:18816382-Chloroquine,
pubmed-meshheading:18816382-Drug Evaluation, Preclinical,
pubmed-meshheading:18816382-Enzyme Inhibitors,
pubmed-meshheading:18816382-Gabon,
pubmed-meshheading:18816382-Humans,
pubmed-meshheading:18816382-Infant,
pubmed-meshheading:18816382-Inhibitory Concentration 50,
pubmed-meshheading:18816382-Molecular Structure,
pubmed-meshheading:18816382-Parasitic Sensitivity Tests,
pubmed-meshheading:18816382-Plasmodium falciparum,
pubmed-meshheading:18816382-Proteasome Endopeptidase Complex
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pubmed:year |
2008
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pubmed:articleTitle |
Comprehensive study of proteasome inhibitors against Plasmodium falciparum laboratory strains and field isolates from Gabon.
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pubmed:affiliation |
Medical Research Unit, Albert Schweitzer Hospital, BP118 Lambaréné, Gabon. akreidenweiss@yahoo.de
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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