| pubmed-article:18815628 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18815628 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:18815628 | lifeskim:mentions | umls-concept:C0001675 | lld:lifeskim |
| pubmed-article:18815628 | lifeskim:mentions | umls-concept:C0229664 | lld:lifeskim |
| pubmed-article:18815628 | lifeskim:mentions | umls-concept:C0162371 | lld:lifeskim |
| pubmed-article:18815628 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:18815628 | lifeskim:mentions | umls-concept:C0814999 | lld:lifeskim |
| pubmed-article:18815628 | lifeskim:mentions | umls-concept:C0007613 | lld:lifeskim |
| pubmed-article:18815628 | lifeskim:mentions | umls-concept:C0039198 | lld:lifeskim |
| pubmed-article:18815628 | lifeskim:mentions | umls-concept:C1579762 | lld:lifeskim |
| pubmed-article:18815628 | lifeskim:mentions | umls-concept:C0009491 | lld:lifeskim |
| pubmed-article:18815628 | pubmed:dateCreated | 2008-9-25 | lld:pubmed |
| pubmed-article:18815628 | pubmed:abstractText | CD25(+)CD4(+) regulatory T cells suppress T cell activation and regulate multiple immune reactions in in vitro and in vivo studies. To define the regulatory function of human CD25(+)CD4(+) T cells at various stages of maturity, we investigated in detail the functional differences of CD25(+)CD4(+) T cells from thymocytes, cord blood (CB), and adult peripheral blood (APB). CB CD25(+)CD4(+) T cells displayed low-FOXP3 protein expression level and had no suppressive activity. In contrast, CD25(+)CD4(+) T cells from thymocytes or APB expressed high expression level of FOXP3 protein associated with significant suppressive activity. Although CB CD25(+)CD4(+) T cells exhibited no suppressive activity, striking suppressive activity was observed following expansion in culture associated with increased FOXP3 expression and a shift from the CD45RA(+) to the CD45RA(-) phenotype. These functional differences in CD25(+)CD4(+) T cells from Thy, CB, and APB hence suggest a pathway of maturation for Treg in the peripheral immune system. | lld:pubmed |
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| pubmed-article:18815628 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18815628 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18815628 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18815628 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18815628 | pubmed:issn | 1740-2530 | lld:pubmed |
| pubmed-article:18815628 | pubmed:author | pubmed-author:MorimotoChika... | lld:pubmed |
| pubmed-article:18815628 | pubmed:author | pubmed-author:KurosawaHirom... | lld:pubmed |
| pubmed-article:18815628 | pubmed:author | pubmed-author:YoshidaSatoko... | lld:pubmed |
| pubmed-article:18815628 | pubmed:author | pubmed-author:UchiyamaTakeh... | lld:pubmed |
| pubmed-article:18815628 | pubmed:author | pubmed-author:OhnumaKeiK | lld:pubmed |
| pubmed-article:18815628 | pubmed:author | pubmed-author:DangNam HNH | lld:pubmed |
| pubmed-article:18815628 | pubmed:author | pubmed-author:TakahashiNozo... | lld:pubmed |
| pubmed-article:18815628 | pubmed:author | pubmed-author:NagatsuMasayo... | lld:pubmed |
| pubmed-article:18815628 | pubmed:author | pubmed-author:FujimakiWakae... | lld:pubmed |
| pubmed-article:18815628 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18815628 | pubmed:volume | 2008 | lld:pubmed |
| pubmed-article:18815628 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18815628 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18815628 | pubmed:pagination | 305859 | lld:pubmed |
| pubmed-article:18815628 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:18815628 | pubmed:meshHeading | pubmed-meshheading:18815628... | lld:pubmed |
| pubmed-article:18815628 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18815628 | pubmed:articleTitle | Comparative study of regulatory T cell function of human CD25CD4 T cells from thymocytes, cord blood, and adult peripheral blood. | lld:pubmed |
| pubmed-article:18815628 | pubmed:affiliation | Division of Clinical Immunology, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan. | lld:pubmed |
| pubmed-article:18815628 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18815628 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18815628 | lld:pubmed |
