Source:http://linkedlifedata.com/resource/pubmed/id/18814143
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
2008-12-1
|
pubmed:abstractText |
Chondrosarcoma is a type of highly malignant tumor with a potent capacity to invade locally and cause distant metastasis. Chondrosarcoma shows a predilection for metastasis to the lungs. The stromal cell-derived factor 1 (SDF-1), constitutively secreted by human lung epithelium cells, has been shown to function in a key role for recruitment of neutrophils. Here, we found that human chondrosarcoma tissues and chondrosarcoma cell lines had significant expression of CXCR4 (SDF-1 receptor), which was higher than normal cartilage and human chondrocyte. SDF-1alpha and lung epithelium cells conditioned medium (LECM) induced the invasiveness of chondrosarcoma cells. SDF-1 siRNA inhibited LECM-induced invasion of chondrosarcoma cells and SDF-1alpha also directly induced the cell surface expression of alphavbeta3 but not alpha2beta1 and alpha5beta1 integrin. Activations of ERK and NF-kappaB pathways after SDF-1 treatment was demonstrated, and SDF-1alpha-induced expression of alphavbeta3 integrin and invasion activity was inhibited by the specific inhibitor and mutant of ERK and NF-kappaB cascades. Taken together, our results indicate that lung derived-SDF-1alpha enhances the invasiveness of chondrosarcoma cells by increasing alphavbeta3 integrin expression through the CXCR4/ERK/NF-kappaB signal transduction pathway.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL12,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Signal-Regulated MAP...,
http://linkedlifedata.com/resource/pubmed/chemical/Integrin alphaVbeta3,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR4
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
1097-4652
|
pubmed:author | |
pubmed:copyrightInfo |
(c) 2008 Wiley-Liss, Inc.
|
pubmed:issnType |
Electronic
|
pubmed:volume |
218
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
334-42
|
pubmed:dateRevised |
2009-11-19
|
pubmed:meshHeading |
pubmed-meshheading:18814143-Cell Line, Tumor,
pubmed-meshheading:18814143-Chemokine CXCL12,
pubmed-meshheading:18814143-Chondrosarcoma,
pubmed-meshheading:18814143-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:18814143-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18814143-Humans,
pubmed-meshheading:18814143-Integrin alphaVbeta3,
pubmed-meshheading:18814143-Models, Biological,
pubmed-meshheading:18814143-NF-kappa B,
pubmed-meshheading:18814143-Neoplasm Invasiveness,
pubmed-meshheading:18814143-Receptors, CXCR4,
pubmed-meshheading:18814143-Signal Transduction,
pubmed-meshheading:18814143-Up-Regulation
|
pubmed:year |
2009
|
pubmed:articleTitle |
Stromal cell-derived factor-1 increase alphavbeta3 integrin expression and invasion in human chondrosarcoma cells.
|
pubmed:affiliation |
Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|