| pubmed-article:18814044 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18814044 | lifeskim:mentions | umls-concept:C0291573 | lld:lifeskim |
| pubmed-article:18814044 | lifeskim:mentions | umls-concept:C0910167 | lld:lifeskim |
| pubmed-article:18814044 | lifeskim:mentions | umls-concept:C0017636 | lld:lifeskim |
| pubmed-article:18814044 | lifeskim:mentions | umls-concept:C0520484 | lld:lifeskim |
| pubmed-article:18814044 | lifeskim:mentions | umls-concept:C1822997 | lld:lifeskim |
| pubmed-article:18814044 | lifeskim:mentions | umls-concept:C1441616 | lld:lifeskim |
| pubmed-article:18814044 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:18814044 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:18814044 | pubmed:dateCreated | 2008-11-17 | lld:pubmed |
| pubmed-article:18814044 | pubmed:abstractText | Development of new therapies for glioblastoma requires animal models that mimic the biological characteristics of human brain tumors. On the other hand, potential antitumoral effects of a new therapeutic strategy are often established by evaluation of tumor cells apoptosis. Caspases are key mediators in the regulation and execution of apoptosis. Caspase-9 is activated during the intrinsic pathway downstream of mitochondria while caspase-3 is an effector caspase that initiates degradation of the cell in the final stages of apoptosis. Bax is a pro-apoptotic member of the Bcl-2 family that play key roles in the regulation of intrinsic apoptotic signaling. In the present study we investigated the immunohistochemical distribution of caspase 3, 9 and Bax in intracranial U87 glioblastoma xenograft. Immunohistochemistry showed that the glioblastoma xenografts contain cells positive for caspase-3, caspase-9, and Bax. | lld:pubmed |
| pubmed-article:18814044 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18814044 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18814044 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18814044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18814044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18814044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18814044 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18814044 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:18814044 | pubmed:issn | 1567-2379 | lld:pubmed |
| pubmed-article:18814044 | pubmed:author | pubmed-author:ChivuMihaelaM | lld:pubmed |
| pubmed-article:18814044 | pubmed:author | pubmed-author:ZarnescuOtili... | lld:pubmed |
| pubmed-article:18814044 | pubmed:author | pubmed-author:BreharFelix... | lld:pubmed |
| pubmed-article:18814044 | pubmed:author | pubmed-author:CiureaAlexand... | lld:pubmed |
| pubmed-article:18814044 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18814044 | pubmed:volume | 39 | lld:pubmed |
| pubmed-article:18814044 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18814044 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18814044 | pubmed:pagination | 561-9 | lld:pubmed |
| pubmed-article:18814044 | pubmed:meshHeading | pubmed-meshheading:18814044... | lld:pubmed |
| pubmed-article:18814044 | pubmed:meshHeading | pubmed-meshheading:18814044... | lld:pubmed |
| pubmed-article:18814044 | pubmed:meshHeading | pubmed-meshheading:18814044... | lld:pubmed |
| pubmed-article:18814044 | pubmed:meshHeading | pubmed-meshheading:18814044... | lld:pubmed |
| pubmed-article:18814044 | pubmed:meshHeading | pubmed-meshheading:18814044... | lld:pubmed |
| pubmed-article:18814044 | pubmed:meshHeading | pubmed-meshheading:18814044... | lld:pubmed |
| pubmed-article:18814044 | pubmed:meshHeading | pubmed-meshheading:18814044... | lld:pubmed |
| pubmed-article:18814044 | pubmed:meshHeading | pubmed-meshheading:18814044... | lld:pubmed |
| pubmed-article:18814044 | pubmed:meshHeading | pubmed-meshheading:18814044... | lld:pubmed |
| pubmed-article:18814044 | pubmed:meshHeading | pubmed-meshheading:18814044... | lld:pubmed |
| pubmed-article:18814044 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18814044 | pubmed:articleTitle | Immunohistochemical localization of caspase-3, caspase-9 and Bax in U87 glioblastoma xenografts. | lld:pubmed |
| pubmed-article:18814044 | pubmed:affiliation | Department of Animal Biology, Faculty of Biology, University of Bucharest, Splaiul Independentei 91-95, R-050095 Bucharest, Romania. otilia@bio.unibuc.ro | lld:pubmed |
| pubmed-article:18814044 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18814044 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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