rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
6
|
pubmed:dateCreated |
2009-5-27
|
pubmed:abstractText |
A rodent model of gastroduodenal-esophageal reflux can result in replacement of squamous esophageal mucosa with intestinal-type columnar mucosa and carcinoma. The validity of this model is debated, as it is unproven whether this mucosa is intestinal metaplasia due to reflux or represents migration of adjacent jejunal mucosa above the anastomosis. The aim of this study was to evaluate the esophageal intestinal-type mucosa in these animals by measuring expression of trefoil factor genes (TFF-1, -2, -3) and comparing it with adjacent jejunum in order to determine its etiology.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
1432-2218
|
pubmed:author |
pubmed-author:ChandrasomaParakramaP,
pubmed-author:DanenbergKathleenK,
pubmed-author:DanenbergPeterP,
pubmed-author:DeMeesterSteven RSR,
pubmed-author:DeMeesterTom RTR,
pubmed-author:DunstChristy MCM,
pubmed-author:HagenJeffrey AJA,
pubmed-author:KuramochiHidekazuH,
pubmed-author:LehmanBethany JBJ,
pubmed-author:MoriRyutaroR,
pubmed-author:OhDaniel SDS
|
pubmed:issnType |
Electronic
|
pubmed:volume |
23
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1346-52
|
pubmed:meshHeading |
pubmed-meshheading:18813976-Animals,
pubmed-meshheading:18813976-Barrett Esophagus,
pubmed-meshheading:18813976-Disease Models, Animal,
pubmed-meshheading:18813976-Esophagus,
pubmed-meshheading:18813976-Gene Expression Regulation,
pubmed-meshheading:18813976-Intestinal Mucosa,
pubmed-meshheading:18813976-Jejunum,
pubmed-meshheading:18813976-Male,
pubmed-meshheading:18813976-Neuropeptides,
pubmed-meshheading:18813976-Peptides,
pubmed-meshheading:18813976-Polymerase Chain Reaction,
pubmed-meshheading:18813976-RNA, Messenger,
pubmed-meshheading:18813976-Rats,
pubmed-meshheading:18813976-Rats, Sprague-Dawley
|
pubmed:year |
2009
|
pubmed:articleTitle |
Validation of a rodent model of Barrett's esophagus using quantitative gene expression profiling.
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pubmed:affiliation |
Department of Surgery, University of Southern California, Los Angeles, CA, USA.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|