Linked Life Data

18813017

Source:http://linkedlifedata.com/resource/pubmed/id/18813017

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2008-10-15
pubmed:abstractText
Hernán et al reanalyzed Nurses' Health Study Data on hormone therapy and heart disease, to explore further the apparent discrepancy for those results compared with findings from the Women's Health Initiative Trial. Hernán et al concludes that differences in time since menopause remains the most plausible explanation for the different findings. Part of the analysis employs application of the "intention-to treat" principle to analyze the observational data. This commentary points out some of the weaknesses inherent in that approach, which combines a major limitation of observational studies-lack of randomization-with a common limitation of trials, imperfect adherence to the assigned treatment.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1531-5487
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
783-4; discussion 789-93
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
ITT for observational data: worst of both worlds?
pubmed:affiliation
Department of Epidemiology, Channing Laboratory, Harvard School of Public Health, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. mstampfer@hsph.harvard.edu
pubmed:publicationType
Editorial, Comment, Research Support, N.I.H., Extramural