Source:http://linkedlifedata.com/resource/pubmed/id/18812458
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2008-11-13
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| pubmed:abstractText |
The fine mapping of polymorphisms influencing cholesterol (CT), triglyceride (TG), and lipoprotein serum levels in human and mouse has provided a wealth of knowledge about the complex genetic architecture of these traits. The extension of these genetic analyses to pigs would be of utmost importance since they constitute a valuable biological and clinical model for the study of coronary artery disease and myocardial infarction. In the present work, we performed a whole genome scan for serum lipid traits in a half-sib Duroc pig population of 350 individuals. Phenotypic registers included total CT, TG, and low (LDL)- and high (HDL)-density lipoprotein serum concentrations at 45 and 190 days of age. This approach allowed us to identify two genomewide significant quantitative trait loci (QTL) for HDL-to-LDL ratio at 45 days (SSC6, 84 cM) and for TG at 190 days (SSC4, 23 cM) as well as a number of chromosomewide significant QTL. The comparison of QTL locations at 45 and 190 days revealed a notable lack of concordance at these two time points, suggesting that the effects of these QTL are age specific. Moreover, we have observed a considerable level of correspondence among the locations of the most significant porcine lipid QTL and those identified in humans. This finding might suggest that, in mammals, diverse polymorphisms located in a common set of genes are involved in the genetic variation of serum lipid levels.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
1531-2267
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| pubmed:author |
pubmed-author:AmillsMarcelM,
pubmed-author:DíazIsabelI,
pubmed-author:GallardoDavidD,
pubmed-author:NogueraJosé LJL,
pubmed-author:PenaRamona NRN,
pubmed-author:Prat-CuffiJosep MJM,
pubmed-author:QuintanillaRaquelR,
pubmed-author:RamírezOscarO,
pubmed-author:ReixachJosepJ,
pubmed-author:SolerJoaquimJ,
pubmed-author:TibauJoanJ,
pubmed-author:VaronaLuisL
|
| pubmed:issnType |
Electronic
|
| pubmed:day |
12
|
| pubmed:volume |
35
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
199-209
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| pubmed:meshHeading |
pubmed-meshheading:18812458-Animals,
pubmed-meshheading:18812458-Cholesterol, HDL,
pubmed-meshheading:18812458-Cholesterol, LDL,
pubmed-meshheading:18812458-Chromosome Mapping,
pubmed-meshheading:18812458-Female,
pubmed-meshheading:18812458-Genome, Human,
pubmed-meshheading:18812458-Genome-Wide Association Study,
pubmed-meshheading:18812458-Genomics,
pubmed-meshheading:18812458-Genotype,
pubmed-meshheading:18812458-Humans,
pubmed-meshheading:18812458-Male,
pubmed-meshheading:18812458-Microsatellite Repeats,
pubmed-meshheading:18812458-Phenotype,
pubmed-meshheading:18812458-Quantitative Trait Loci,
pubmed-meshheading:18812458-Species Specificity,
pubmed-meshheading:18812458-Swine,
pubmed-meshheading:18812458-Time Factors,
pubmed-meshheading:18812458-Triglycerides
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Mapping of quantitative trait loci for cholesterol, LDL, HDL, and triglyceride serum concentrations in pigs.
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| pubmed:affiliation |
Departament de Ciència Animal i dels Aliments, Universitat Autònoma de Barcelona, Bellaterra, Spain. raquel.quintanilla@irta.cat
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|