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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1991-9-27
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pubmed:abstractText |
Male adult Wistar rats received daily (at 9 a.m. and 5 p.m.) 10 micrograms of zinc-protamine glucagon by subcutaneous injection for 8 days. Plasma cholesterol levels were decreased by 36% in fed rats, 33% in cholesterol-fed rats and by 55% in fasted rats. Lipoproteins were separated into 22 fractions by ultracentrifugation using a density gradient. Glucagon administration decreased the cholesterol content in all lipoproteins except low density lipoprotein (LDL1) (1.006-1.040) and very low density lipoprotein (VLDL) from cholesterol-fed rats. The main decrease (-57 to -81%) was observed in 1.050-1.100 g/mL lipoproteins (LDL2 and HDL2), which contained a large amount of apo E, while HDL3 cholesterol was not affected. Triacylglycerol levels were decreased only in chylomicrons and VLDL (-70%) of fed and cholesterol-fed rats, while plasma and lipoprotein triacylglycerol levels were not changed in fasted rats treated with glucagon. In normally fed rats glucagon administration increased by 42% the fractional catabolic rate of [125I]HDL2 while the absolute catabolic rate appeared to be unchanged. Glucagon seems to be a potent hypolipidemic agent affecting mainly the apo E-rich lipoproteins. Its chronic administration limits lipoprotein accumulation which occurs upon cholesterol feeding.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins E,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, VLDL,
http://linkedlifedata.com/resource/pubmed/chemical/Chylomicrons,
http://linkedlifedata.com/resource/pubmed/chemical/Glucagon,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, HDL2,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipids,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0024-4201
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
451-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1881241-Animals,
pubmed-meshheading:1881241-Apolipoproteins E,
pubmed-meshheading:1881241-Centrifugation, Density Gradient,
pubmed-meshheading:1881241-Cholesterol,
pubmed-meshheading:1881241-Cholesterol, HDL,
pubmed-meshheading:1881241-Cholesterol, LDL,
pubmed-meshheading:1881241-Cholesterol, VLDL,
pubmed-meshheading:1881241-Chylomicrons,
pubmed-meshheading:1881241-Fasting,
pubmed-meshheading:1881241-Glucagon,
pubmed-meshheading:1881241-Lipoproteins,
pubmed-meshheading:1881241-Lipoproteins, HDL,
pubmed-meshheading:1881241-Lipoproteins, HDL2,
pubmed-meshheading:1881241-Male,
pubmed-meshheading:1881241-Phospholipids,
pubmed-meshheading:1881241-Rats,
pubmed-meshheading:1881241-Rats, Inbred Strains,
pubmed-meshheading:1881241-Triglycerides
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pubmed:year |
1991
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pubmed:articleTitle |
Effect of chronic glucagon administration on lipoprotein composition in normally fed, fasted and cholesterol-fed rats.
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pubmed:affiliation |
Unité de Recherches sur les Dyslipidémies et l'Atherosclérose, INSERM U 32 Hôpital Henri-Mondor, Créteil, France.
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pubmed:publicationType |
Journal Article
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