Linked Life Data

18812013

Source:http://linkedlifedata.com/resource/pubmed/id/18812013

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-2-19
pubmed:abstractText
The recreational drug 3,4-methylenedioxy-metamphetamine (MDMA; 'ecstasy') enhances serotonin and dopamine transmission. Repeated binge treatment with MDMA (5 mg/kg, 3 times daily, 3 h apart, once per week for 4 wk) was found to increase gene expression of S100B, a neurotrophic factor that modulates neuronal plasticity. Mutant mice overexpressing S100B were investigated to better understand how increased S100B expression may influence MDMA-induced biochemical and behavioural responses. In open-field behaviour, the later MDMA binges decreased rearing and thigmotaxis in S100B mutant mice compared to wild-type mice. In the elevated plus-maze, MDMA increased open-arm entries in both genotypes, but less tolerance to this effect was found in S100B mutant mice. Serotonin transporter (SERT) density was up-regulated in the substantia nigra in S100B mutant mice under baseline conditions. MDMA treatment increased SERT in wild-type mice, but did not further increase it in S100B mutant mice. Dopamine transporter density was down-regulated by MDMA in both genotypes in the striatum. 5-HT1B receptor density and G-protein coupling were higher in MDMA-treated S100B mutant mice than in saline-treated mutant mice and MDMA-treated wild-type mice in the medial globus pallidus. In conclusion, repeated MDMA treatment increases S100B mRNA. Certain explorative and anxiolytic-like behaviours in response to MDMA are potentiated and exhibit less tolerance in mice overexpressing S100B. The genotype-dependent behavioural responses are paralleled by adaptations in the serotonin system. Our data indicate that genetic differences in S100B gene expression may predispose individual differences in the responsivity to repeated intake of MDMA.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1469-5111
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
201-15
pubmed:meshHeading
pubmed-meshheading:18812013-Analysis of Variance, pubmed-meshheading:18812013-Animals, pubmed-meshheading:18812013-Autoradiography, pubmed-meshheading:18812013-Behavior, Animal, pubmed-meshheading:18812013-Brain, pubmed-meshheading:18812013-Brain Chemistry, pubmed-meshheading:18812013-Dopamine Plasma Membrane Transport Proteins, pubmed-meshheading:18812013-Drug Administration Schedule, pubmed-meshheading:18812013-Exploratory Behavior, pubmed-meshheading:18812013-Gene Expression, pubmed-meshheading:18812013-Gene Expression Regulation, pubmed-meshheading:18812013-Guanosine 5'-O-(3-Thiotriphosphate), pubmed-meshheading:18812013-Hallucinogens, pubmed-meshheading:18812013-Locomotion, pubmed-meshheading:18812013-Maze Learning, pubmed-meshheading:18812013-Mice, pubmed-meshheading:18812013-Mice, Inbred C57BL, pubmed-meshheading:18812013-Mice, Mutant Strains, pubmed-meshheading:18812013-N-Methyl-3,4-methylenedioxyamphetamine, pubmed-meshheading:18812013-Nerve Growth Factors, pubmed-meshheading:18812013-Protein Binding, pubmed-meshheading:18812013-RNA, Messenger, pubmed-meshheading:18812013-Receptor, Serotonin, 5-HT1B, pubmed-meshheading:18812013-S100 Proteins, pubmed-meshheading:18812013-Serotonin Plasma Membrane Transport Proteins, pubmed-meshheading:18812013-Time Factors
pubmed:year
2009
pubmed:articleTitle
S100B overexpressing mutant mice exhibit prolonged behavioural and biochemical responses towards repeated intermittent binge treatments with MDMA.
pubmed:affiliation
Section of Translational Neuropharmacology, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. anna.kindlundh@fyfa.ki.se
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't