Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
39
pubmed:dateCreated
2008-10-1
pubmed:abstractText
Naturally acquired immune responses against human cancers often include CD8(+) T cells specific for the cancer testis antigen NY-ESO-1. Here, we studied T cell receptor (TCR) primary structure and function of 605 HLA-A*0201/NY-ESO-1(157-165)-specific CD8 T cell clones derived from five melanoma patients. We show that an important proportion of tumor-reactive T cells preferentially use TCR AV3S1/BV8S2 chains, with remarkably conserved CDR3 amino acid motifs and lengths in both chains. All remaining T cell clones belong to two additional sets expressing BV1 or BV13 TCRs, associated with alpha-chains with highly diverse VJ usage, CDR3 amino acid sequence, and length. Yet, all T cell clonotypes recognize tumor antigen with similar functional avidity. Two residues, Met-160 and Trp-161, located in the middle region of the NY-ESO-1(157-165) peptide, are critical for recognition by most of the T cell clonotypes. Collectively, our data show that a large number of alphabeta TCRs, belonging to three distinct sets (AVx/BV1, AV3/BV8, AVx/BV13) bind pMHC with equal antigen sensitivity and recognize the same peptide motif. Finally, this in-depth study of recognition of a self-antigen suggests that in part similar biophysical mechanisms shape TCR repertoires toward foreign and self-antigens.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18809922-10969798, http://linkedlifedata.com/resource/pubmed/commentcorrection/18809922-11280765, http://linkedlifedata.com/resource/pubmed/commentcorrection/18809922-11300471, http://linkedlifedata.com/resource/pubmed/commentcorrection/18809922-11937585, http://linkedlifedata.com/resource/pubmed/commentcorrection/18809922-11956290, http://linkedlifedata.com/resource/pubmed/commentcorrection/18809922-12555663, http://linkedlifedata.com/resource/pubmed/commentcorrection/18809922-12615890, http://linkedlifedata.com/resource/pubmed/commentcorrection/18809922-12734356, http://linkedlifedata.com/resource/pubmed/commentcorrection/18809922-12796775, http://linkedlifedata.com/resource/pubmed/commentcorrection/18809922-15040585, http://linkedlifedata.com/resource/pubmed/commentcorrection/18809922-15596521, http://linkedlifedata.com/resource/pubmed/commentcorrection/18809922-15664164, http://linkedlifedata.com/resource/pubmed/commentcorrection/18809922-15716973, http://linkedlifedata.com/resource/pubmed/commentcorrection/18809922-15837811, http://linkedlifedata.com/resource/pubmed/commentcorrection/18809922-15838382, http://linkedlifedata.com/resource/pubmed/commentcorrection/18809922-16488988, http://linkedlifedata.com/resource/pubmed/commentcorrection/18809922-16551255, http://linkedlifedata.com/resource/pubmed/commentcorrection/18809922-17082594, http://linkedlifedata.com/resource/pubmed/commentcorrection/18809922-17323415, http://linkedlifedata.com/resource/pubmed/commentcorrection/18809922-17644531, http://linkedlifedata.com/resource/pubmed/commentcorrection/18809922-17658550, http://linkedlifedata.com/resource/pubmed/commentcorrection/18809922-17675498, http://linkedlifedata.com/resource/pubmed/commentcorrection/18809922-1833769, http://linkedlifedata.com/resource/pubmed/commentcorrection/18809922-4133807, http://linkedlifedata.com/resource/pubmed/commentcorrection/18809922-7527444, http://linkedlifedata.com/resource/pubmed/commentcorrection/18809922-7964506, http://linkedlifedata.com/resource/pubmed/commentcorrection/18809922-8254673, http://linkedlifedata.com/resource/pubmed/commentcorrection/18809922-9584143
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1091-6490
pubmed:author
pubmed:issnType
Electronic
pubmed:day
30
pubmed:volume
105
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
15010-5
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Distinct sets of alphabeta TCRs confer similar recognition of tumor antigen NY-ESO-1157-165 by interacting with its central Met/Trp residues.
pubmed:affiliation
Division of Clinical Onco-Immunology, Ludwig Institute for Cancer Research, New York, NY, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't