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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2008-10-9
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pubmed:abstractText |
Monoclonal free light chains (FLCs) frequently cause rapidly progressive renal failure in patients with multiple myeloma. Immunoassays which provide quantitative measurement of FLCs in serum, have now been adopted into screening algorithms for multiple myeloma and other lymphoproliferative disorders. The assays indicate monoclonal FLC production by the presence of an abnormal kappa to lambda FLC ratio (reference range 0.26-1.65). Previous work, however, has demonstrated that in patients with renal failure the FLC ratio can be increased above normal with no other evidence of monoclonal proteins suggesting that in this population the range should be extended (reference range 0.37-3.1). This study evaluated the diagnostic sensitivity and specificity of the immunoassays in patients with severe renal failure.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18808676-11274017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18808676-12194920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18808676-12401845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18808676-12583950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18808676-12780789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18808676-12823348,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18808676-15902843,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18808676-16682511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18808676-16858075,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18808676-17229909,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18808676-17768111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18808676-2183734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18808676-2601255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18808676-3621685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18808676-3937021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18808676-4165739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18808676-8547129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18808676-9060087,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18808676-9759684
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2369
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18808676-Adult,
pubmed-meshheading:18808676-Aged,
pubmed-meshheading:18808676-Aged, 80 and over,
pubmed-meshheading:18808676-Biological Markers,
pubmed-meshheading:18808676-Female,
pubmed-meshheading:18808676-Humans,
pubmed-meshheading:18808676-Immunoglobulin Light Chains,
pubmed-meshheading:18808676-Male,
pubmed-meshheading:18808676-Middle Aged,
pubmed-meshheading:18808676-Multiple Myeloma,
pubmed-meshheading:18808676-Renal Insufficiency,
pubmed-meshheading:18808676-Severity of Illness Index,
pubmed-meshheading:18808676-Young Adult
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pubmed:year |
2008
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pubmed:articleTitle |
Serum free light chain measurement aids the diagnosis of myeloma in patients with severe renal failure.
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pubmed:affiliation |
Department of Nephrology, University Hospital Birmingham, UK. cah692@bham.ac.uk
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pubmed:publicationType |
Journal Article,
Comparative Study
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