Linked Life Data

1880819

Source:http://linkedlifedata.com/resource/pubmed/id/1880819

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1991-10-2
pubmed:abstractText
The effect of coronary and intraventricular pressures on the glucose uptake and its transmural distribution was studied in isolated, beating rat heart perfused using the Langendorff procedure. Left ventricular glucose uptake measured by the deoxyglucose method, and the effect of coronary (aortic) pressure was dissociated from intraventricular pressure development by draining the left ventricle. Left ventricular glucose uptake was 2.6 +/- 0.1 mumols/min per g protein (mean +/- S.E.M.) and 35 +/- 6% higher (P less than 0.001) in the subendocardium than in the subepicardium under control conditions (aortic pressure 80 cm H2O, non-drained). Elimination of the intraventricular pressure development caused no significant change in the total left ventricular glucose uptake or its transmural distribution. Increase in the aortic pressure to 150 cmH2O accelerated glucose uptake in non-drained and drained hearts by 57-75%. The increase in the glucose uptake was more pronounced in the subepicardial layer than in the subendocardial layer, so that the transmural gradient decreased by 27-32% (P less than 0.001) in non-drained and drained hearts. The results indicate that in Langendorff-perfused heart the effect of aortic pressure on the total glucose uptake and its transmural distribution across the left ventricular wall is not mediated through intraventricular pressure development, but through the coronary pressure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-2828
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
381-5
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Coronary pressure determines regional glucose uptake in the left ventricular wall of the heart.
pubmed:affiliation
Department of Sports Medicine, University of Oulu, Finland.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't