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rdf:type |
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lifeskim:mentions |
umls-concept:C0014653,
umls-concept:C0017262,
umls-concept:C0085862,
umls-concept:C0185117,
umls-concept:C0278701,
umls-concept:C1299583,
umls-concept:C1337027,
umls-concept:C1337109,
umls-concept:C1514474,
umls-concept:C1549571,
umls-concept:C1608386,
umls-concept:C2911684
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pubmed:issue |
12
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pubmed:dateCreated |
2008-12-16
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pubmed:abstractText |
Dysregulation of apoptosis is a key factor in carcinogenesis and tumor progression. X-linked inhibitor of apoptosis (XIAP) is the most potent member of the inhibitor of apoptosis protein (IAP) family, which directly inhibits apoptosis by binding to caspases. Antagonists of XIAP have recently been identified: second mitochondria-derived activator of caspase/direct IAP-binding protein with low PI (Smac/DIABLO) and XIAP-associated factor 1 (XAF1). However, little research has been conducted on the association between gastric cancer survival and the mechanism of apoptosis involving XIAP and its antagonists, Smac/DIABLO and XAF1.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1534-4681
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3579-87
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pubmed:dateRevised |
2010-9-10
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pubmed:meshHeading |
pubmed-meshheading:18807090-Adenocarcinoma,
pubmed-meshheading:18807090-Adult,
pubmed-meshheading:18807090-Aged,
pubmed-meshheading:18807090-Aged, 80 and over,
pubmed-meshheading:18807090-Apoptosis,
pubmed-meshheading:18807090-Female,
pubmed-meshheading:18807090-Humans,
pubmed-meshheading:18807090-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:18807090-Lymphatic Metastasis,
pubmed-meshheading:18807090-Male,
pubmed-meshheading:18807090-Middle Aged,
pubmed-meshheading:18807090-Mitochondrial Proteins,
pubmed-meshheading:18807090-Neoplasm Proteins,
pubmed-meshheading:18807090-Prognosis,
pubmed-meshheading:18807090-Stomach Neoplasms,
pubmed-meshheading:18807090-Survival Rate,
pubmed-meshheading:18807090-X-Linked Inhibitor of Apoptosis Protein,
pubmed-meshheading:18807090-Zinc Fingers
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pubmed:year |
2008
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pubmed:articleTitle |
Disturbed XIAP and XAF1 expression balance is an independent prognostic factor in gastric adenocarcinomas.
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pubmed:affiliation |
Department of Oncological Science Surgery II, Faculty of Medicine, Oita University, Yufu City, Oita, Japan. shiba@med.oita-u.ac.jp
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pubmed:publicationType |
Journal Article
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