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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2008-10-21
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pubmed:abstractText |
Mice deficient in the interferon-gamma (IFN-gamma)-inducible, immunity-related GTPase Irgm1 have defective host resistance to a variety of intracellular pathogens. This greater susceptibility to infection is associated with impaired IFN-gamma-dependent macrophage microbicidal activity in vitro. Here we show that Irgm1 also regulated the survival of mature effector CD4(+) T lymphocytes by protecting them from IFN-gamma-induced autophagic cell death. Mice deficient in both IFN-gamma and Irgm1 were 'rescued' from the lymphocyte depletion and greater mortality that occurs in mice singly deficient in Irgm1 after mycobacterial infection. Our studies identify a feedback mechanism in the T helper type 1 response that limits the detrimental effects of IFN-gamma on effector T lymphocyte survival while promoting the antimicrobial functions of IFN-gamma.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-10490099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-10604474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-10880532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-10880533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-11306591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-11907070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-12094224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-12172546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-12370261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-1255758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-12574375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-12640450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-12810105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-12974476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-14576437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-14707092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-15035850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-15040583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-15131264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-15558033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-15607973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-15864272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-15899915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-15908387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-16200202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-16237051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-16339555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-16702227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-16886061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-16888103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-17190837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-17589543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-17617585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-17717517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-17767194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-17969446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-18064049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-18178823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-18275825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-18305538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-18371424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-18936780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-2147950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-7502050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-7535182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-7561525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-7618088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-9144497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-9432980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18806793-9862701
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1529-2916
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pubmed:author |
pubmed-author:BáficaAndréA,
pubmed-author:CannonsJennifer LJL,
pubmed-author:CasparPatriciaP,
pubmed-author:ChaussabelDamienD,
pubmed-author:FengCarl GCG,
pubmed-author:HienySaraS,
pubmed-author:JankovicDraganaD,
pubmed-author:LenardoMichael JMJ,
pubmed-author:SchwartzbergPamela LPL,
pubmed-author:SherAlanA,
pubmed-author:WatfordWendy TWT,
pubmed-author:ZhengLixinL
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1279-87
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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