| pubmed-article:18804997 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18804997 | lifeskim:mentions | umls-concept:C0008059 | lld:lifeskim |
| pubmed-article:18804997 | lifeskim:mentions | umls-concept:C0023449 | lld:lifeskim |
| pubmed-article:18804997 | lifeskim:mentions | umls-concept:C0035020 | lld:lifeskim |
| pubmed-article:18804997 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:18804997 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:18804997 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:18804997 | lifeskim:mentions | umls-concept:C1517060 | lld:lifeskim |
| pubmed-article:18804997 | lifeskim:mentions | umls-concept:C1709634 | lld:lifeskim |
| pubmed-article:18804997 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:18804997 | pubmed:dateCreated | 2008-10-30 | lld:pubmed |
| pubmed-article:18804997 | pubmed:abstractText | We report on the efficiency of treatment of first isolated extramedullary relapse of B-cell precursor acute lymphoblastic leukaemia. Sixty-eight children and adolescents were included in the trial COPRALL-97. Stratification criteria were time to relapse: first complete remission duration of less than 24 months for group G3A (n=35), relapse beyond 24 months for group G3B (n=33). Treatment consisted of risk-adapted alternating short course multiagent systemic and intrathecal chemotherapy and irradiation (18Gy). Event free survival (EFS) and overall survival (OS) for all registered patients at 6 years were 43% and 55%, respectively. EFS at 4 years for patients of group G3A and G3B were, respectively, 31% and 61% (p=0.0071) while OS at 4 years were, respectively, 40% and 76% (p=0.065). Our analyses highlighted two independent risks factors predictive of decreased EFS: early relapse and age at the initial diagnosis above 6 years. Early central nervous system relapses have a bad prognosis, and new therapeutic strategies are needed. | lld:pubmed |
| pubmed-article:18804997 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18804997 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18804997 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18804997 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18804997 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:18804997 | pubmed:issn | 1879-0852 | lld:pubmed |
| pubmed-article:18804997 | pubmed:author | pubmed-author:BenoitYvesY | lld:pubmed |
| pubmed-article:18804997 | pubmed:author | pubmed-author:MercierMariet... | lld:pubmed |
| pubmed-article:18804997 | pubmed:author | pubmed-author:BordigoniPier... | lld:pubmed |
| pubmed-article:18804997 | pubmed:author | pubmed-author:LevergerGuyG | lld:pubmed |
| pubmed-article:18804997 | pubmed:author | pubmed-author:BaruchelAndré... | lld:pubmed |
| pubmed-article:18804997 | pubmed:author | pubmed-author:MichelGérardG | lld:pubmed |
| pubmed-article:18804997 | pubmed:author | pubmed-author:PlouvierEmman... | lld:pubmed |
| pubmed-article:18804997 | pubmed:author | pubmed-author:BertrandYvesY | lld:pubmed |
| pubmed-article:18804997 | pubmed:author | pubmed-author:DomenechCarin... | lld:pubmed |
| pubmed-article:18804997 | pubmed:author | pubmed-author:PuraveauMarcM | lld:pubmed |
| pubmed-article:18804997 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18804997 | pubmed:volume | 44 | lld:pubmed |
| pubmed-article:18804997 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18804997 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18804997 | pubmed:pagination | 2461-9 | lld:pubmed |
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| pubmed-article:18804997 | pubmed:meshHeading | pubmed-meshheading:18804997... | lld:pubmed |
| pubmed-article:18804997 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18804997 | pubmed:articleTitle | First isolated extramedullary relapse in children with B-cell precursor acute lymphoblastic leukaemia: results of the Cooprall-97 study. | lld:pubmed |
| pubmed-article:18804997 | pubmed:affiliation | Service d'Immuno-Hématologie Pédiatrique, Institut d'Hématologie et Oncologie Pédiatrique, Hospices Civils de Lyon, Université Claude Bernard Lyon1, Lyon Cedex 08, France. carine_halfon@yahoo.fr | lld:pubmed |
| pubmed-article:18804997 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18804997 | pubmed:publicationType | Multicenter Study | lld:pubmed |
