Source:http://linkedlifedata.com/resource/pubmed/id/18804997
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
16
|
| pubmed:dateCreated |
2008-10-30
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| pubmed:abstractText |
We report on the efficiency of treatment of first isolated extramedullary relapse of B-cell precursor acute lymphoblastic leukaemia. Sixty-eight children and adolescents were included in the trial COPRALL-97. Stratification criteria were time to relapse: first complete remission duration of less than 24 months for group G3A (n=35), relapse beyond 24 months for group G3B (n=33). Treatment consisted of risk-adapted alternating short course multiagent systemic and intrathecal chemotherapy and irradiation (18Gy). Event free survival (EFS) and overall survival (OS) for all registered patients at 6 years were 43% and 55%, respectively. EFS at 4 years for patients of group G3A and G3B were, respectively, 31% and 61% (p=0.0071) while OS at 4 years were, respectively, 40% and 76% (p=0.065). Our analyses highlighted two independent risks factors predictive of decreased EFS: early relapse and age at the initial diagnosis above 6 years. Early central nervous system relapses have a bad prognosis, and new therapeutic strategies are needed.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
|
| pubmed:issn |
1879-0852
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
44
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2461-9
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| pubmed:meshHeading |
pubmed-meshheading:18804997-Adolescent,
pubmed-meshheading:18804997-Age of Onset,
pubmed-meshheading:18804997-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:18804997-Central Nervous System Neoplasms,
pubmed-meshheading:18804997-Child,
pubmed-meshheading:18804997-Child, Preschool,
pubmed-meshheading:18804997-Combined Modality Therapy,
pubmed-meshheading:18804997-Disease-Free Survival,
pubmed-meshheading:18804997-Female,
pubmed-meshheading:18804997-Humans,
pubmed-meshheading:18804997-Infant,
pubmed-meshheading:18804997-Male,
pubmed-meshheading:18804997-Neoplasm Recurrence, Local,
pubmed-meshheading:18804997-Ovarian Neoplasms,
pubmed-meshheading:18804997-Precursor B-Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:18804997-Stem Cell Transplantation,
pubmed-meshheading:18804997-Testicular Neoplasms,
pubmed-meshheading:18804997-Treatment Outcome,
pubmed-meshheading:18804997-Young Adult
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
First isolated extramedullary relapse in children with B-cell precursor acute lymphoblastic leukaemia: results of the Cooprall-97 study.
|
| pubmed:affiliation |
Service d'Immuno-Hématologie Pédiatrique, Institut d'Hématologie et Oncologie Pédiatrique, Hospices Civils de Lyon, Université Claude Bernard Lyon1, Lyon Cedex 08, France. carine_halfon@yahoo.fr
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| pubmed:publicationType |
Journal Article,
Multicenter Study
|