Linked Life Data

18804454

Source:http://linkedlifedata.com/resource/pubmed/id/18804454

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-10-20
pubmed:abstractText
Infection of human erythrocytes with the malaria parasite Plasmodium falciparum induces activation of organic osmolyte and anion channels in the host cell membrane. These channels supply the intraerythrocytic parasite with nutrients, dispose of metabolic waste products, adjust the host electrolyte concentrations to the parasite's needs, and lower the colloid osmotic pressure, thus preventing premature hemolysis of the osmotically challenged host cell. Four different types of anion channels (CFTR, ClC-2 or PSAC, an 18pS inward rectifier, and an 80pS outward rectifier) have been identified in human erythrocytes. Here, we show that the 80pS channels underlie a serum albumin-dependent anion current. Both, the parasite in vitro development and the organic osmolyte permeability of the parasitized erythrocyte, reportedly depend on serum albumin, highlighting the pivotal functional significance of the 80pS channel for the intraerythrocytic parasite development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1090-2104
pubmed:author
pubmed:issnType
Electronic
pubmed:day
21
pubmed:volume
376
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
514-8
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Organic osmolyte channels in malaria-infected erythrocytes.
pubmed:affiliation
Department of Radiation Oncology, Eberhard-Karls-University Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany. stephan.huber@uni-tuebingen.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't