Linked Life Data

18804304

Source:http://linkedlifedata.com/resource/pubmed/id/18804304

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2008-11-12
pubmed:abstractText
Fragile X syndrome is associated with expansion of a CGG triplet repeat in the FMR1 gene, which abolishes production of the FMRP protein. This abnormality is expressed as a number of neuro-endocrine disorders (the adrenal axis, macroorchidism) and the emergence of significant behavioural stress. Here, we report on the hormonal status of a young adult with fragile X syndrome, with a focus on catecholamine and cortisol changes during a submaximal treadmill test. The patient showed abnormally high epinephrine and norepinephrine concentrations. During a submaximal incremental test, cortisol levels were higher than the laboratory reference range. Although the submaximal incremental test has a significant "stressful" effect, this young adult was able to complete the entire protocol without any maladaptive behaviour or withdrawal.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1768-3203
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
683-7, 687-91
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Maximal and submaximal treadmill tests in a young adult with fragile-X syndrome.
pubmed:affiliation
UF de médecine du sport et des activités physiques, pôle physiologie-rééducation, clinique physiologie, sommeil, exercice, IFR1-recherche exercice santé, CHU Sud, avenue de Kimberley, 38130 Echirolles, France. vbricout@chu-grenoble.fr
pubmed:publicationType
Journal Article, Case Reports