Linked Life Data

18804107

Source:http://linkedlifedata.com/resource/pubmed/id/18804107

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
23-24
pubmed:dateCreated
2008-11-3
pubmed:abstractText
The poor prognosis of glioblastoma patients is related to diffuse brain invasion and interaction of tumor cells with extracellular matrices (ECM). We describe expression and function of the FACIT-collagen XVI in glioblastomas. We found upregulation of collagen XVI mRNA as well as protein in glioblastomas as compared to normal cortex. SiRNA knockdown resulted in decreased cell adhesion whereas increased adhesion was observed on surfaces coated with collagen XVI. The migration of glioblastoma cells on this substrate remained unchanged. Our results demonstrate de-novo expression of collagen XVI in glioblastomas as part of the tumor specific remodeling of the ECM.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0014-5793
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
582
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3293-300
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Collagen XVI expression is upregulated in glioblastomas and promotes tumor cell adhesion.
pubmed:affiliation
Institute of Neuropathology, University Hospital Muenster, Domagkstrasse 19, D-48149 Muenster, Germany. senner@uni-muenster.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't