Linked Life Data

18802101

Source:http://linkedlifedata.com/resource/pubmed/id/18802101

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2008-9-19
pubmed:abstractText
Myeloid dendritic cells (DC) and macrophages play an important role in pathogen sensing and antimicrobial defense. In this study we provide evidence that myeloid DC respond to infection with Listeria monocytogenes with simultaneous induction of multiple stimulatory and inhibitory molecules. However, the overall impact of infected DC during T cell encounter results in suppression of T cell activation, indicating that inhibitory pathways functionally predominate. Inhibitory activity of infected DC is effected mainly by IL-10 and cyclooxygenase 2-mediated mechanisms, with soluble CD25 acting as an IL-2 scavenger as well as by the products of tryptophan catabolism. These inhibitory pathways are strictly TNF-dependent. In addition to direct infection, DC bearing this regulatory phenotype can be induced in vitro by a combination of signals including TNF, TLR2, and prostaglandin receptor ligation and by supernatants derived from the infected cells. Both infection-associated DC and other in vitro-induced regulatory DC are characterized by increased resistance to infection and enhanced bactericidal activity. Furthermore, myeloid DC expressing multiple regulatory molecules are identified in vivo in granuloma during listeriosis and tuberculosis. Based on the in vivo findings and the study of in vitro models, we propose that in granulomatous infections regulatory DC may possess dual function evolved to protect the host from disseminating infection via inhibition of granuloma destruction by T cells and control of pathogen spreading.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1550-6606
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
181
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4976-88
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:18802101-Adjuvants, Immunologic, pubmed-meshheading:18802101-Cell Differentiation, pubmed-meshheading:18802101-Cell Line, pubmed-meshheading:18802101-Cells, Cultured, pubmed-meshheading:18802101-Coculture Techniques, pubmed-meshheading:18802101-Dendritic Cells, pubmed-meshheading:18802101-Down-Regulation, pubmed-meshheading:18802101-Enzyme Induction, pubmed-meshheading:18802101-Granuloma, pubmed-meshheading:18802101-Growth Inhibitors, pubmed-meshheading:18802101-Humans, pubmed-meshheading:18802101-Immunophenotyping, pubmed-meshheading:18802101-Immunosuppressive Agents, pubmed-meshheading:18802101-Indoleamine-Pyrrole 2,3,-Dioxygenase, pubmed-meshheading:18802101-Listeria monocytogenes, pubmed-meshheading:18802101-Listeriosis, pubmed-meshheading:18802101-Macrophages, pubmed-meshheading:18802101-Monocytes, pubmed-meshheading:18802101-Myeloid Cells, pubmed-meshheading:18802101-Signal Transduction, pubmed-meshheading:18802101-T-Lymphocyte Subsets
pubmed:year
2008
pubmed:articleTitle
Infection of myeloid dendritic cells with Listeria monocytogenes leads to the suppression of T cell function by multiple inhibitory mechanisms.
pubmed:affiliation
Genomics and Immunoregulation, Institute for Life and Medical Sciences, University of Bonn, Bonn, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't