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rdf:type |
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lifeskim:mentions |
umls-concept:C0001074,
umls-concept:C0017262,
umls-concept:C0023175,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0038435,
umls-concept:C0145988,
umls-concept:C0185117,
umls-concept:C0205267,
umls-concept:C0392747,
umls-concept:C0439596,
umls-concept:C0443172,
umls-concept:C0443254,
umls-concept:C0584869,
umls-concept:C0623362,
umls-concept:C0728907,
umls-concept:C0871712,
umls-concept:C0919336,
umls-concept:C1515926,
umls-concept:C1708715,
umls-concept:C2346689,
umls-concept:C2911684
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pubmed:issue |
10
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pubmed:dateCreated |
2010-7-30
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pubmed:abstractText |
Tendinopathy commonly occurs in tendons with large in vivo loading demands like the Achilles tendon (AT) and supraspinatus tendon (SST). In addition to differences in their local anatomic environment, these tendons are designed for different loading requirements because of the muscles to which they attach, with the AT experiencing higher loads than the SST. One possible factor in the progression of tendinopathy is the interplay between mechanical loading and the regulation of enzymes that degrade the extracellular matrix (matrix metalloproteinases (MMPs)) and their inhibitors (tissue inhibitor of metalloprotienases (TIMPs)). Thus, overuse injuries may have different biological consequences in tendons designed for different in vivo loading demands.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1473-0480
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
698-703
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pubmed:meshHeading |
pubmed-meshheading:18801769-Achilles Tendon,
pubmed-meshheading:18801769-Animals,
pubmed-meshheading:18801769-Biomechanics,
pubmed-meshheading:18801769-In Situ Hybridization,
pubmed-meshheading:18801769-Male,
pubmed-meshheading:18801769-Matrix Metalloproteinase 13,
pubmed-meshheading:18801769-Matrix Metalloproteinase 3,
pubmed-meshheading:18801769-Rats,
pubmed-meshheading:18801769-Rats, Sprague-Dawley,
pubmed-meshheading:18801769-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:18801769-Rotator Cuff,
pubmed-meshheading:18801769-Stress, Mechanical,
pubmed-meshheading:18801769-Tendinopathy,
pubmed-meshheading:18801769-Tissue Inhibitor of Metalloproteinase-2,
pubmed-meshheading:18801769-Up-Regulation
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pubmed:year |
2010
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pubmed:articleTitle |
Changes in mechanical loading lead to tendonspecific alterations in MMP and TIMP expression: influence of stress deprivation and intermittent cyclic hydrostatic compression on rat supraspinatus and Achilles tendons.
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pubmed:affiliation |
Department of Surgery, University of Calgary, 451A Heritage Medical Research Building, 3330 Hospital Dr NW, Calgary, Alberta T2N4N1, Canada. gail.thornton@ucalgary.ca
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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