Source:http://linkedlifedata.com/resource/pubmed/id/18801081
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2008-9-19
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| pubmed:abstractText |
The distinction between tubular carcinomas (TC) and invasive well-differentiated (grade 1) ductal carcinoma (IDC) is important given treatment and prognostic differences. Studies have described a strong association between flat epithelial atypia (FEA) and TC. The incidence of FEA associated with grade 1 IDC is not well established. The aim of the present study was to assess morphology and intra-epithelial lesions between 14 TC and 18 grade 1 IDC matched for size. Of 14 TC, eight (57%) had associated FEA, seven (50%) had micropapillary atypical ductal hyperplasia (ADH), three (21%) had low nuclear grade ductal carcinoma in situ (DCIS), and four (29%) had lobular neoplasia. Notably, only two of 18 (11%) grade 1 IDC had associated FEA. Three of 18 (16%) grade 1 IDC had ADH, two (11%) had lobular neoplasia, and seven (39%) had DCIS. All tubular carcinomas were estrogen receptor (ER) positive and negative for Her-2/neu overexpression. All grade 1 IDC were ER positive but 5% also overexpressed Her-2/neu. Axillary lymph node metastasis was present in 11% of grade 1 IDC and absent in TC. A strong association was found between TC, FEA, and micropapillary ADH, which may reflect a biological progression. Despite matching for tumor size, grade 1 IDC have a higher incidence of lymph node metastasis and may have Her-2-neu overexpression compared to TC.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ERBB2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, erbB-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Estrogen,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Progesterone,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
|
| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
|
| pubmed:issn |
1440-1827
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
58
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
620-5
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:18801081-Adenocarcinoma,
pubmed-meshheading:18801081-Adult,
pubmed-meshheading:18801081-Aged,
pubmed-meshheading:18801081-Aged, 80 and over,
pubmed-meshheading:18801081-Breast Neoplasms,
pubmed-meshheading:18801081-Carcinoma, Ductal, Breast,
pubmed-meshheading:18801081-Carcinoma, Intraductal, Noninfiltrating,
pubmed-meshheading:18801081-Cell Nucleus,
pubmed-meshheading:18801081-Epithelial Cells,
pubmed-meshheading:18801081-Female,
pubmed-meshheading:18801081-Humans,
pubmed-meshheading:18801081-In Situ Hybridization, Fluorescence,
pubmed-meshheading:18801081-Lymph Nodes,
pubmed-meshheading:18801081-Lymphatic Metastasis,
pubmed-meshheading:18801081-Middle Aged,
pubmed-meshheading:18801081-Prognosis,
pubmed-meshheading:18801081-Receptor, erbB-2,
pubmed-meshheading:18801081-Receptors, Estrogen,
pubmed-meshheading:18801081-Receptors, Progesterone,
pubmed-meshheading:18801081-Tumor Markers, Biological
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| pubmed:year |
2008
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| pubmed:articleTitle |
Tubular carcinoma and grade 1 (well-differentiated) invasive ductal carcinoma: comparison of flat epithelial atypia and other intra-epithelial lesions.
|
| pubmed:affiliation |
Department of Pathology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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