Linked Life Data

18799548

Source:http://linkedlifedata.com/resource/pubmed/id/18799548

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-12-31
pubmed:abstractText
Vitamin E was previously reported to reduce calcium oxalate (CaOx) crystal formation. This study explored whether vitamin E deficiency affects intrarenal oxidative stress and accelerates crystal deposition in hyperoxaluria. The control (C) group of rats received a standard diet and drinking water, while the experimental groups received 0.75% ethylene glycol (EG) in drinking water for 42 days. Of the latter, one group received a standard diet (EG group), one received a low-vitamin E (LE) diet (EG+LE group), and the last received an LE diet with vitamin E supplement (4 mg) (EG+LE+E group). The C+LE and C+LE+E groups were the specific controls for the last two experimental groups, respectively. In a separate experiment, EG and EG+LE rats were studied on days 3-42 to examine the temporal relationship between oxidative change and crystal formation. Urinary biochemistry and activity/levels of antioxidative and oxidative enzymes in glomeruli and tubulointerstitial specimens (TIS) were examined. In EG rats, CaOx crystal accumulation was associated with low antioxidative enzyme activity in TIS and with increased oxidative enzyme expression in glomeruli. In the EG+LE group, marked changes in antioxidative and oxidative enzyme levels were seen and correlated with massive CaOx deposition and tubular damage. The increased oxidative stress seen with EG+LE treatment was largely reversed by vitamin E supplementation. A temporal study showed that decrease in antioxidative defense and increased free radical formation in the EG+LE group occurred before crystal deposition. This study shows that low vitamin E disrupts the redox balance and causes cell death, thereby favoring crystal formation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1931-857X
pubmed:author
pubmed:issnType
Print
pubmed:volume
296
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
F34-45
pubmed:dateRevised
2011-4-28
pubmed:meshHeading
pubmed-meshheading:18799548-Animals, pubmed-meshheading:18799548-Calcium Oxalate, pubmed-meshheading:18799548-Crystallization, pubmed-meshheading:18799548-Dietary Supplements, pubmed-meshheading:18799548-Disease Models, Animal, pubmed-meshheading:18799548-Ethylene Glycol, pubmed-meshheading:18799548-Free Radicals, pubmed-meshheading:18799548-Hyperoxaluria, pubmed-meshheading:18799548-Kidney, pubmed-meshheading:18799548-Male, pubmed-meshheading:18799548-Membrane Glycoproteins, pubmed-meshheading:18799548-NADPH Oxidase, pubmed-meshheading:18799548-Oxidative Stress, pubmed-meshheading:18799548-Rats, pubmed-meshheading:18799548-Rats, Wistar, pubmed-meshheading:18799548-Superoxides, pubmed-meshheading:18799548-Vitamin E, pubmed-meshheading:18799548-Vitamin E Deficiency, pubmed-meshheading:18799548-Xanthine Oxidase
pubmed:year
2009
pubmed:articleTitle
Low-vitamin E diet exacerbates calcium oxalate crystal formation via enhanced oxidative stress in rat hyperoxaluric kidney.
pubmed:affiliation
Dept. of Urology, National Taiwan Univ. Hospital, Yun-Lin Branch #582, Section 2, Yun-Lin Road, Douliou City, Taiwan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't