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18799311
Source:
http://linkedlifedata.com/resource/pubmed/id/18799311
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rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0053697
,
umls-concept:C0220781
,
umls-concept:C0243071
,
umls-concept:C0599533
,
umls-concept:C0871161
,
umls-concept:C1883254
pubmed:issue
20
pubmed:dateCreated
2008-10-20
pubmed:abstractText
The synthesis of mono- and bisphosphorothioate analogues of 3',5'-cyclic diguanylic acid (cdiGMP) via the modified H-phosphonate chemistry is reported. The immunostimulatory properties of these analogues were compared with those of cdiGMP.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic GMP
,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphates
,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphonic Acids
,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines
,
http://linkedlifedata.com/resource/pubmed/chemical/bis(3',5')-cyclic diguanylic acid
,
http://linkedlifedata.com/resource/pubmed/chemical/thiophosphoric acid
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1464-3405
pubmed:author
pubmed-author:ChenWangxueW
,
pubmed-author:KuoLeeRhondaR
,
pubmed-author:WangXiaoluX
,
pubmed-author:YanHongbinH
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5631-4
pubmed:meshHeading
pubmed-meshheading:18799311-Bronchi
,
pubmed-meshheading:18799311-Chemistry, Pharmaceutical
,
pubmed-meshheading:18799311-Chromatography, High Pressure Liquid
,
pubmed-meshheading:18799311-Cyclic GMP
,
pubmed-meshheading:18799311-Dose-Response Relationship, Drug
,
pubmed-meshheading:18799311-Drug Design
,
pubmed-meshheading:18799311-Humans
,
pubmed-meshheading:18799311-Immune System
,
pubmed-meshheading:18799311-Inflammation
,
pubmed-meshheading:18799311-Models, Chemical
,
pubmed-meshheading:18799311-Neutrophils
,
pubmed-meshheading:18799311-Phosphates
,
pubmed-meshheading:18799311-Phosphonic Acids
,
pubmed-meshheading:18799311-Vaccines
pubmed:year
2008
pubmed:articleTitle
Synthesis and immunostimulatory properties of the phosphorothioate analogues of cdiGMP.
pubmed:affiliation
Department of Chemistry, Brock University, 500 Glenridge Avenue, St. Catharines, Ont., Canada L2S 3A1. tyan@brocku.ca
pubmed:publicationType
Journal Article
,
Research Support, Non-U.S. Gov't