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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2009-3-11
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pubmed:abstractText |
Centrosome duplication normally parallels with DNA replication and is responsible for correct segregation of replicated DNA into the daughter cells. Although geminin interacts with Cdt1 to prevent loading of MCMs (minichromosome maintenance proteins) on to the replication origins, inactivation of geminin nevertheless causes centrosome over-duplication in addition to the re-replication of the genome, suggesting that geminin may play a role in centrosome duplication. However, the exact mechanism by which loss of geminin affects centrosomal duplication remains unclear and the possible direct interaction of geminin with centrosomal-localized proteins is still unidentified.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798731-10454562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798731-10620802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798731-10671377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798731-10766247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798731-10811826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798731-10837229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798731-11125146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798731-11358861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798731-11555648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798731-11756470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798731-12045100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798731-12192004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798731-12415252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798731-1356230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798731-14993212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798731-15004027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798731-15064746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798731-15157458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798731-15159417,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18798731-3670402,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18798731-9635433
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1768-322X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
273-85
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pubmed:dateRevised |
2010-9-21
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pubmed:meshHeading |
pubmed-meshheading:18798731-COUP Transcription Factor II,
pubmed-meshheading:18798731-Cell Cycle,
pubmed-meshheading:18798731-Cell Cycle Proteins,
pubmed-meshheading:18798731-Centrosome,
pubmed-meshheading:18798731-Dyneins,
pubmed-meshheading:18798731-Gene Expression Regulation,
pubmed-meshheading:18798731-HeLa Cells,
pubmed-meshheading:18798731-Humans,
pubmed-meshheading:18798731-Hydroxyurea,
pubmed-meshheading:18798731-Microtubule-Associated Proteins,
pubmed-meshheading:18798731-Microtubules
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pubmed:year |
2009
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pubmed:articleTitle |
Geminin is partially localized to the centrosome and plays a role in proper centrosome duplication.
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pubmed:affiliation |
The MOE Key Laboratory of Cell Proliferation and Differentiation, College of Life Sciences, Peking University, Beijing 100871, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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