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pubmed-article:18798075pubmed:abstractTextThe MOSAIC trial showed that the use of adjuvant oxaliplatin and an infusional regimen of 5-FU/LV in the treatment of stage II/III colon cancer improved disease-free survival (DFS). The NSABP's C-07 trial evaluated the addition of oxaliplatin to a weekly Roswell Park regimen of bolus 5-FU/LV and found a similar improvement in DFS. The benefit of oxaliplatin appears to be independent of the 5-FU/LV regimen used. This paper reviews the efficacy and toxicities of these two regimens and is meant to serve as a guide for clinical practice.lld:pubmed
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pubmed-article:18798075pubmed:authorpubmed-author:O'ConnellMich...lld:pubmed
pubmed-article:18798075pubmed:authorpubmed-author:WolmarkNorman...lld:pubmed
pubmed-article:18798075pubmed:authorpubmed-author:YothersGregGlld:pubmed
pubmed-article:18798075pubmed:authorpubmed-author:SharifSaimaSlld:pubmed
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pubmed-article:18798075pubmed:dateRevised2011-9-26lld:pubmed
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pubmed-article:18798075pubmed:articleTitleFOLFOX and FLOX regimens for the adjuvant treatment of resected stage II and III colon cancer.lld:pubmed
pubmed-article:18798075pubmed:affiliationNational Surgical Adjuvant Breast and Bowel Project Operations Office, Pittsburgh, Pennsylvania, USA. saima.sharif@nsabp.orglld:pubmed
pubmed-article:18798075pubmed:publicationTypeJournal Articlelld:pubmed
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