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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2008-11-26
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pubmed:abstractText |
The MOSAIC trial showed that the use of adjuvant oxaliplatin and an infusional regimen of 5-FU/LV in the treatment of stage II/III colon cancer improved disease-free survival (DFS). The NSABP's C-07 trial evaluated the addition of oxaliplatin to a weekly Roswell Park regimen of bolus 5-FU/LV and found a similar improvement in DFS. The benefit of oxaliplatin appears to be independent of the 5-FU/LV regimen used. This paper reviews the efficacy and toxicities of these two regimens and is meant to serve as a guide for clinical practice.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/U10 CA012027-30,
http://linkedlifedata.com/resource/pubmed/grant/U10 CA012027-31,
http://linkedlifedata.com/resource/pubmed/grant/U10 CA012027-31S1,
http://linkedlifedata.com/resource/pubmed/grant/U10 CA012027-32,
http://linkedlifedata.com/resource/pubmed/grant/U10 CA012027-32S1,
http://linkedlifedata.com/resource/pubmed/grant/U10 CA012027-33,
http://linkedlifedata.com/resource/pubmed/grant/U10 CA012027-33S1,
http://linkedlifedata.com/resource/pubmed/grant/U10 CA012027-33S2,
http://linkedlifedata.com/resource/pubmed/grant/U10 CA012027-34,
http://linkedlifedata.com/resource/pubmed/grant/U10 CA012027-35,
http://linkedlifedata.com/resource/pubmed/grant/U10 CA012027-36,
http://linkedlifedata.com/resource/pubmed/grant/U10 CA012027-37,
http://linkedlifedata.com/resource/pubmed/grant/U10 CA012027-37S1,
http://linkedlifedata.com/resource/pubmed/grant/U10 CA012027-38,
http://linkedlifedata.com/resource/pubmed/grant/U10 CA037377-15,
http://linkedlifedata.com/resource/pubmed/grant/U10 CA037377-16,
http://linkedlifedata.com/resource/pubmed/grant/U10 CA037377-17,
http://linkedlifedata.com/resource/pubmed/grant/U10 CA037377-18,
http://linkedlifedata.com/resource/pubmed/grant/U10 CA037377-19,
http://linkedlifedata.com/resource/pubmed/grant/U10 CA037377-20,
http://linkedlifedata.com/resource/pubmed/grant/U10 CA037377-21,
http://linkedlifedata.com/resource/pubmed/grant/U10 CA037377-22,
http://linkedlifedata.com/resource/pubmed/grant/U10 CA069651-11,
http://linkedlifedata.com/resource/pubmed/grant/U10 CA069651-12,
http://linkedlifedata.com/resource/pubmed/grant/U10 CA069651-13,
http://linkedlifedata.com/resource/pubmed/grant/U10 CA069651-14,
http://linkedlifedata.com/resource/pubmed/grant/U10 CA069651-15,
http://linkedlifedata.com/resource/pubmed/grant/U10 CA069974-10,
http://linkedlifedata.com/resource/pubmed/grant/U10 CA069974-11,
http://linkedlifedata.com/resource/pubmed/grant/U10 CA069974-11S2,
http://linkedlifedata.com/resource/pubmed/grant/U10 CA069974-12,
http://linkedlifedata.com/resource/pubmed/grant/U10CA-12027,
http://linkedlifedata.com/resource/pubmed/grant/U10CA-37377,
http://linkedlifedata.com/resource/pubmed/grant/U10CA-69651,
http://linkedlifedata.com/resource/pubmed/grant/U10CA-69974
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798075-10744089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798075-10944126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798075-14665611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798075-15175435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798075-15175436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798075-15269313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798075-16260700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798075-17470850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798075-17470851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798075-17470858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798075-17853393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798075-3073651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798075-8410113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18798075-9053508
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1532-4192
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
956-63
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:18798075-Adjuvants, Immunologic,
pubmed-meshheading:18798075-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:18798075-Colonic Neoplasms,
pubmed-meshheading:18798075-Disease-Free Survival,
pubmed-meshheading:18798075-Female,
pubmed-meshheading:18798075-Fluorouracil,
pubmed-meshheading:18798075-Humans,
pubmed-meshheading:18798075-Leucovorin,
pubmed-meshheading:18798075-Male,
pubmed-meshheading:18798075-Middle Aged,
pubmed-meshheading:18798075-Neoplasm Staging,
pubmed-meshheading:18798075-Organoplatinum Compounds,
pubmed-meshheading:18798075-Practice Guidelines as Topic,
pubmed-meshheading:18798075-Randomized Controlled Trials as Topic,
pubmed-meshheading:18798075-Treatment Outcome
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pubmed:year |
2008
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pubmed:articleTitle |
FOLFOX and FLOX regimens for the adjuvant treatment of resected stage II and III colon cancer.
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pubmed:affiliation |
National Surgical Adjuvant Breast and Bowel Project Operations Office, Pittsburgh, Pennsylvania, USA. saima.sharif@nsabp.org
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pubmed:publicationType |
Journal Article
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