Linked Life Data

18798045

Source:http://linkedlifedata.com/resource/pubmed/id/18798045

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2011-2-14
pubmed:abstractText
A new nutraceutical carrier, chitosan-coated nano-size liposome, which is itself bioactive, is made from phosphatidylcholine (pc) and cholesterol by the sonication method. Different factors related to the size of the liposomes such as the ratio of the pc and cholesterol and the time of sonication are investigated. At the 40 : 60 ratios of pc and cholesterol with 12 min sonication, the smallest liposomes, with mean diameter ?82 nm, were obtained. Incorporation of chemically labile active ingredients into the chitosan-coated liposomes prevented chemical degradation, which is shown for vitamin E (VE). After VE was loaded to the liposomes, the size of chitosan-coated liposomes increased to 144 nm. The loading efficiency and payload of VE were investigated by loading different amounts of VE to the liposomes which were prepared with different ratios of pc and cholesterol. Chitosan-coated nano-coated nano-size liposomes appeared to be promising VE carriers, with highest loading efficiency over 99% and payload over 27%. The stability of VE-loaded liposomes suspension during the 8 weeks storage is over 90% under 4°C.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1464-5246
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
235-42
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Chitosan-coated nanoliposome as vitamin E carrier.
pubmed:affiliation
Graduate School Biotechnology, Korea University, Sungbuk-Ku, Seoul, South Korea.
pubmed:publicationType
Journal Article