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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1991-10-3
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pubmed:abstractText |
A hybridocytochemical approach has been applied to establish whether the gene for the C/EBP mRNA might be involved in the topographical regulation of gene expression in adult rat liver. To that end the spatial distribution of the mRNA of C/EBP has been compared to that of the mRNAs of glutamine synthetase (GS), phosphoenolpyruvate carboxykinase (PEPCK) and glucokinase (GK) in normal adult livers, in livers from dexamethasone-treated animals and in livers from starved animals refed with glucose for 4 h. In normal rat liver, in situ hybridization with a probe for C/EBP mRNA revealed a low density of apparently homogeneously distributed grains, indicating low levels of C/EBP mRNA. In contrast, the livers of the experimentally-treated animals revealed a zonal distribution of the mRNA of C/EBP with the highest density of grains around the central venules. The dynamics of the pattern of expression of C/EBP mRNA are virtually identical to that of the GK mRNA. These data qualify C/EBP mRNA as a pericentral mRNA and suggest a role for the C/EBP protein in the topographical regulation of the expression of the GK mRNA.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
288
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
133-7
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:1879546-Animals,
pubmed-meshheading:1879546-Base Sequence,
pubmed-meshheading:1879546-CCAAT-Enhancer-Binding Proteins,
pubmed-meshheading:1879546-DNA-Binding Proteins,
pubmed-meshheading:1879546-Dexamethasone,
pubmed-meshheading:1879546-Gene Expression Regulation,
pubmed-meshheading:1879546-Glucokinase,
pubmed-meshheading:1879546-Glutamate Synthase,
pubmed-meshheading:1879546-Liver,
pubmed-meshheading:1879546-Molecular Sequence Data,
pubmed-meshheading:1879546-Nuclear Proteins,
pubmed-meshheading:1879546-Nucleic Acid Hybridization,
pubmed-meshheading:1879546-Phosphoenolpyruvate Carboxykinase (GTP),
pubmed-meshheading:1879546-RNA, Messenger,
pubmed-meshheading:1879546-Rats,
pubmed-meshheading:1879546-Rats, Inbred Strains,
pubmed-meshheading:1879546-Starvation,
pubmed-meshheading:1879546-Transcription, Genetic,
pubmed-meshheading:1879546-Transcription Factors
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pubmed:year |
1991
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pubmed:articleTitle |
The dynamics of the expression of C/EBP mRNA in the adult rat liver lobulus qualifies it as a pericentral mRNA.
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pubmed:affiliation |
Department of Anatomy and Embryology, University of Amsterdam, The Netherlands.
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pubmed:publicationType |
Journal Article
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