Linked Life Data

18795192

Source:http://linkedlifedata.com/resource/pubmed/id/18795192

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2008-9-16
pubmed:abstractText
Since the advent of cyclooxygenase 2 (COX-2) inhibitors, little research has been done on the effects of these medications on fracture healing. In the study reported here, we sought to determine whether a COX-2 inhibitor, celecoxib, affects strength and amount of healing callus formed after a fracture. Forty-eight male Sprague-Dawley rats were evaluated for impairment of fracture healing with celecoxib use. Compared with controls, celecoxib-treated rats had a significant decrease in force required for refracture (P = .0199). We do not recommend routine use of celecoxib in postfracture pain control, particularly when fracture union is tenuous.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1934-3418
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
E133-7
pubmed:dateRevised
2010-1-5
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Effects of a cyclooxygenase 2 inhibitor on fracture healing in a rat model.
pubmed:affiliation
Department of Orthopaedic Surgery, Wright State University School of Medicine, Dayton, OH 45409, USA. maherbenick@mvh.org
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't