Linked Life Data

1879501

Source:http://linkedlifedata.com/resource/pubmed/id/1879501

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-10-3
pubmed:abstractText
We documented the comparative histogenesis and timing of development of Bruch's membrane (complexus basalis) in five mammalian models with different lengths of gestation. Retinas with attached choroid from the central posterior pole of the eye were obtained from hamster, vole, rabbit, ferret and cat, from mid-gestation onward until the time at which all components of Bruch's membrane could be detected. The sequence of events in the development of Bruch's membrane was similar among species, however the time of appearance of the components varied. At mid-gestation, the basement membrane of the retinal pigment epithelium (RPE) was present to some degree in all species and microfibrils were developing in the connective tissue space external to the RPE basement membrane. The appearance of an initially scant endothelial basement membrane around the choriocapillaries occurred on post-natal (P) day 1 (P1) in hamster, pre-natal (E) day 20 (E20) in vole, E16 in rabbit, P2 in ferret, and E48 in cat. Among the microfibrils within the connective tissue space external to the RPE, electron-dense islands presumed to be elastin were detected on P7 in hamster, P9 in vole, E24 in rabbit, P19 in ferret, and P1 in cat. Relative to birth date and eye opening, the components of Bruch's membrane in the ferret were detected at a later date than that of the other species studied. However, relative to the interval from conception to the appearance of the components of Bruch's membrane, the ferret and cat are similar, paralleling their similar intervals from conception to eye opening.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0014-4835
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
47-54
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Comparative histogenesis of Bruch's membrane (complexus basalis).
pubmed:affiliation
Howe Laboratory of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston.
pubmed:publicationType
Journal Article, Comparative Study