18794343

Source:http://linkedlifedata.com/resource/pubmed/id/18794343

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0018866, umls-concept:C0441712, umls-concept:C0542341
pubmed:issue	18
pubmed:dateCreated	2008-9-16
pubmed:abstractText	The Hedgehog (Hh) family of proteins control cell growth, survival, and fate, and pattern almost every aspect of the vertebrate body plan. The use of a single morphogen for such a wide variety of functions is possible because cellular responses to Hh depend on the type of responding cell, the dose of Hh received, and the time cells are exposed to Hh. The Hh gradient is shaped by several proteins that are specifically required for Hh processing, secretion, and transport through tissues. The mechanism of cellular response, in turn, incorporates multiple feedback loops that fine-tune the level of signal sensed by the responding cells. Germline mutations that subtly affect Hh pathway activity are associated with developmental disorders, whereas somatic mutations activating the pathway have been linked to multiple forms of human cancer. This review focuses broadly on our current understanding of Hh signaling, from mechanisms of action to cellular and developmental functions. In addition, we review the role of Hh in the pathogenesis of human disease and the possibilities for therapeutic intervention.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8711660
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Hedgehog Proteins
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	0890-9369
pubmed:author	pubmed-author:TaipaleJussiJ, pubmed-author:VarjosaloMarkkuM
pubmed:issnType	Print
pubmed:day	15
pubmed:volume	22
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	2454-72
pubmed:meshHeading	pubmed-meshheading:18794343-Animals, pubmed-meshheading:18794343-Body Patterning, pubmed-meshheading:18794343-Cell Division, pubmed-meshheading:18794343-Cell Lineage, pubmed-meshheading:18794343-Cell Survival, pubmed-meshheading:18794343-Hedgehog Proteins, pubmed-meshheading:18794343-Humans
pubmed:year	2008
pubmed:articleTitle	Hedgehog: functions and mechanisms.
pubmed:affiliation	Department of Molecular Medicine, National Public Health Institute (KTL), and Genome-Scale Biology Program, Biomedicum Helsinki, Institute of Biomedicine and High Throughput Center, Faculty of Medicine, University of Helsinki, Helsinki FI-00014, Finland.
pubmed:publicationType	Journal Article, Review, Research Support, Non-U.S. Gov't