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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-9-16
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pubmed:abstractText |
Boron neutron capture therapy (BNCT) is a radiotherapeutic modality based on (10)B(n,alpha)(7)Li reaction, for the treatment of malignant gliomas. One of the main limitations for BNCT effectiveness is the insufficient intake of (10)B nuclei in the tumor cells. This work was aimed at investigating the use of L-DOPA as a putative enhancer for (10)B-drug 4-dihydroxy-borylphenylalanine (BPA) uptake in the C6-glioma model. The investigation was first performed in vitro and then extended to the animal model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0360-3016
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pubmed:author |
pubmed-author:BozzaliMarcoM,
pubmed-author:CamettiCesareC,
pubmed-author:CapuaniSilviaS,
pubmed-author:ColasantiMarcoM,
pubmed-author:D'AmoreEmanuelaE,
pubmed-author:GiliTommasoT,
pubmed-author:LazzarinoGiuseppeG,
pubmed-author:MaravigliaBrunoB,
pubmed-author:PastoreFrancesco SFS,
pubmed-author:PorcariPaolaP,
pubmed-author:RussoSalvatoreS,
pubmed-author:VenturiniGiorgioG
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
562-7
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pubmed:meshHeading |
pubmed-meshheading:18793958-Animals,
pubmed-meshheading:18793958-Boron Compounds,
pubmed-meshheading:18793958-Boron Neutron Capture Therapy,
pubmed-meshheading:18793958-Brain,
pubmed-meshheading:18793958-Brain Neoplasms,
pubmed-meshheading:18793958-Dopamine Agents,
pubmed-meshheading:18793958-Glioma,
pubmed-meshheading:18793958-Levodopa,
pubmed-meshheading:18793958-Male,
pubmed-meshheading:18793958-Phenylalanine,
pubmed-meshheading:18793958-Rats
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pubmed:year |
2008
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pubmed:articleTitle |
L-DOPA preloading increases the uptake of borophenylalanine in C6 glioma rat model: a new strategy to improve BNCT efficacy.
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pubmed:affiliation |
Physics Department, Sapienza University of Rome, Italy; Enrico Fermi Center, Rome, Italy. silvia.capuani@roma1.infn.it
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pubmed:publicationType |
Journal Article
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