Linked Life Data

18792562

Source:http://linkedlifedata.com/resource/pubmed/id/18792562

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5-6
pubmed:dateCreated
2008-9-16
pubmed:abstractText
Anagrelide is an imidazokinazoline derivate that reduces platelet production by interfering with megakaryocyte proliferation and maturation. As a non-cytostatic drug it selectively affects megakaryocyte lineage and therefore anemia and leukocytopenia are not likely to occur. This makes anagrelide adequate for the treatment of chronic myeloproliferative disorders characterized by marked thrombocytemia. In this study we have evaluated efficacy of anagrelide in 14 pretreated patients with essential thrombocytemia. The response was achieved in 11 patients (78%) and was defined as a platelet count lower than 450 x 10(9)/l or 700 x 10(9)/l without thrombohemorrhagic incidents. The therapy was stopped in 6 patients; three patients did not respond to treatment; one had a serious side effect; pregnancy was the reason for discontinuation of therapy in one patient, and in one patient therapy was changed by his own request. We can conclude that anagrelide is an effective and safe drug for pretreated patients with essential thrombocythemia.
pubmed:language
hrv
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0024-3477
pubmed:author
pubmed:issnType
Print
pubmed:volume
130
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
141-5
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:articleTitle
[Anagrelide for treatment of patients with essential thrombocythaemia].
pubmed:affiliation
Zavod za hematologiju Klinike za unutrainje bolesti KBC-a Zagreb i Medicinskog fakulteta Sveucilista u Zagrebu. ana.boban@zg.t-com.hr
pubmed:publicationType
Journal Article, Clinical Trial, English Abstract