Linked Life Data

18791473

Source:http://linkedlifedata.com/resource/pubmed/id/18791473

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2008-10-3
pubmed:abstractText
In nine patients with essential tremor (14 thalami), the authors varied frequency, voltage, and pulsewidth of thalamic deep brain stimulation, and quantified postural tremor. Low frequency stimulation aggravated tremor; the effect increased with increasing voltage. High frequency stimulation had a U-shaped relation to voltage, with minimum tremor at an optimal voltage characteristic of the individual thalamus and increases in voltage beyond the optimum reduced tremor suppression.Based on the hypothesis that tremor response to deep brain stimulation resulted from two competing processes, the authors successfully modeled the relationship of tremor to voltage and frequency of stimulation using a mathematical model. The optimum voltage predicted by the model agreed with the empirically measured value. Moreover, the model made accurate predictions at high stimulation frequency based on measurements made at low stimulation frequency.Our results indicate there is an optimal voltage for tremor suppression by thalamic deep brain stimulation in most patients with essential tremor. The optimum varies across patients, and this is related to electrode position. A mathematical model based on "competing processes" successfully predicts optimum voltage in individual patients. This supports a competing processes model of deep brain stimulation effects.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1537-1603
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
265-73
pubmed:dateRevised
2011-5-3
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
A model predicting optimal parameters for deep brain stimulation in essential tremor.
pubmed:affiliation
Department of Neurology, Center for Neurological Restoration Cleveland Clinic Foundation, Cleveland, Ohio, USA. coopers2@ccf.org
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural