Source:http://linkedlifedata.com/resource/pubmed/id/18789487
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2008-11-25
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| pubmed:abstractText |
The proteolytic destruction of cyclin B is an important event during cell division. Cyclin B proteolysis is triggered by the anaphase-promoting complex. Therefore, cell cycle dysregulation due to anaphase-promoting complex loss contributes to cell transformation and human carcinogenesis. This study investigates anaphase-promoting complex7 expression in spindle cell breast tumors and also includes a comparison between the proliferation antigen Ki-67 and S-phase fraction. The average values of the anaphase-promoting complex7 and Ki-67 labeling indices increased in order from benign to malignant within the phyllodes tumor group, and the fibroadenoma and juvenile fibroadenoma exhibited lower levels of anaphase-promoting complex7 and Ki-67 expression than did the phyllodes tumor. The frequency of anaphase-promoting complex7-positive stromal cells correlated with Ki-67 expression in phyllodes tumor and in all of the examined breast tumors. The above results indicate that anaphase-promoting complex7 and Ki-67 are closely related to cell proliferation. In addition, phyllodes tumor can be differentiated from juvenile fibroadenoma with increased mitotic figures mimicking phyllodes tumor by anaphase-promoting complex7 and Ki-67 immunochemistry. Because anaphase-promoting complex7 is expressed at higher levels than is Ki-67, it may overcome the limitations of the Ki-67 labeling index with regard to the differentiation of benign phyllodes tumor from fibroadenoma.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1532-8392
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
40
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
98-107
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| pubmed:meshHeading |
pubmed-meshheading:18789487-Adolescent,
pubmed-meshheading:18789487-Adult,
pubmed-meshheading:18789487-Breast Neoplasms,
pubmed-meshheading:18789487-Child,
pubmed-meshheading:18789487-Child, Preschool,
pubmed-meshheading:18789487-Female,
pubmed-meshheading:18789487-Fibroadenoma,
pubmed-meshheading:18789487-Flow Cytometry,
pubmed-meshheading:18789487-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18789487-Humans,
pubmed-meshheading:18789487-Immunohistochemistry,
pubmed-meshheading:18789487-Ki-67 Antigen,
pubmed-meshheading:18789487-Middle Aged,
pubmed-meshheading:18789487-Phyllodes Tumor,
pubmed-meshheading:18789487-Retrospective Studies,
pubmed-meshheading:18789487-S Phase,
pubmed-meshheading:18789487-Ubiquitin-Protein Ligase Complexes,
pubmed-meshheading:18789487-Young Adult
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| pubmed:year |
2009
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| pubmed:articleTitle |
Expression of anaphase-promoting complex7 in fibroadenomas and phyllodes tumors of breast.
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| pubmed:affiliation |
Institute for Medical Science, Ajou University School of Medicine, Suwon 443-721, Korea.
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| pubmed:publicationType |
Journal Article
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