Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2008-9-12
pubmed:abstractText
Post-traumatic stress disorder (PTSD) is a stress-related mental disorder caused by traumatic experience. Single-prolonged stress (SPS) is one of the animal models proposed for PTSD. Rats exposed to SPS showed enhanced inhibition of the hypothalamo-pituitary-adrenal (HPA) axis, which has been reliably reproduced in patients with PTSD. Mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) in the hippocampus regulate HPA axis by glucocorticoid negative feedback. Abnormalities in negative feedback are found in PTSD, suggesting that GR and MR might be involved in the pathophysiology of these disorders.In the present study, we performed immunohistochemistry and western blotting to examine the changes in hippocampal MR- and GR-expression after SPS. Immunohistochemistry revealed decreased MR- and GR-immunoreactivity (ir) in the CA1 of hippocampus in SPS animals. Change in GR sub-distribution was also observed, where GR-ir was shifted from nucleus to cytoplasm in SPS rats. Western blotting showed that SPS induced significantly decreased MR- and GR-protein in the whole hippocampus, although the degree of decreased expression of both receptors was different. Meanwhile, we also found the MR/GR ratio decreased in SPS rats. In general, SPS induced down-regulation of MR- and GR-expression. These findings suggest that MR and GR play critical roles in affecting hippocampal function. Changes in MR/GR ratio may be relevant for behavioral syndrome in PTSD.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18787639-10633533, http://linkedlifedata.com/resource/pubmed/commentcorrection/18787639-11274650, http://linkedlifedata.com/resource/pubmed/commentcorrection/18787639-11278286, http://linkedlifedata.com/resource/pubmed/commentcorrection/18787639-12847391, http://linkedlifedata.com/resource/pubmed/commentcorrection/18787639-1484851, http://linkedlifedata.com/resource/pubmed/commentcorrection/18787639-15569889, http://linkedlifedata.com/resource/pubmed/commentcorrection/18787639-15740800, http://linkedlifedata.com/resource/pubmed/commentcorrection/18787639-16533592, http://linkedlifedata.com/resource/pubmed/commentcorrection/18787639-1661614, http://linkedlifedata.com/resource/pubmed/commentcorrection/18787639-17031709, http://linkedlifedata.com/resource/pubmed/commentcorrection/18787639-1933312, http://linkedlifedata.com/resource/pubmed/commentcorrection/18787639-2558306, http://linkedlifedata.com/resource/pubmed/commentcorrection/18787639-7952288, http://linkedlifedata.com/resource/pubmed/commentcorrection/18787639-8080346, http://linkedlifedata.com/resource/pubmed/commentcorrection/18787639-8252612, http://linkedlifedata.com/resource/pubmed/commentcorrection/18787639-8274434, http://linkedlifedata.com/resource/pubmed/commentcorrection/18787639-8532822, http://linkedlifedata.com/resource/pubmed/commentcorrection/18787639-8584606, http://linkedlifedata.com/resource/pubmed/commentcorrection/18787639-8618925, http://linkedlifedata.com/resource/pubmed/commentcorrection/18787639-8728567, http://linkedlifedata.com/resource/pubmed/commentcorrection/18787639-9088000, http://linkedlifedata.com/resource/pubmed/commentcorrection/18787639-9459546, http://linkedlifedata.com/resource/pubmed/commentcorrection/18787639-9582422, http://linkedlifedata.com/resource/pubmed/commentcorrection/18787639-9626555, http://linkedlifedata.com/resource/pubmed/commentcorrection/18787639-9869331, http://linkedlifedata.com/resource/pubmed/commentcorrection/18787639-9918224
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:month
Aug
pubmed:issn
0044-5991
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
89-95
pubmed:dateRevised
2009-11-18
pubmed:year
2008
pubmed:articleTitle
Expressions of hippocampal mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) in the single-prolonged stress-rats.
pubmed:affiliation
Department of Histology and Embryology, Basic Medical College, China Medical University, Shenyang, China.
pubmed:publicationType
Journal Article