| pubmed-article:1878748 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1878748 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:1878748 | lifeskim:mentions | umls-concept:C0012356 | lld:lifeskim |
| pubmed-article:1878748 | lifeskim:mentions | umls-concept:C0221464 | lld:lifeskim |
| pubmed-article:1878748 | lifeskim:mentions | umls-concept:C0205054 | lld:lifeskim |
| pubmed-article:1878748 | lifeskim:mentions | umls-concept:C0012359 | lld:lifeskim |
| pubmed-article:1878748 | lifeskim:mentions | umls-concept:C0004916 | lld:lifeskim |
| pubmed-article:1878748 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:1878748 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1878748 | pubmed:dateCreated | 1991-9-27 | lld:pubmed |
| pubmed-article:1878748 | pubmed:abstractText | 1. This study was carried out in order to identify the receptor responsible for adenosine-induced dilatation of the hepatic arterial vascular bed. 2. Livers of 10 New Zealand White rabbits were perfused in vitro with Krebs-Bülbring buffer via the hepatic artery and the portal vein at constant flows of 26 and 77 ml min-1 100 g-1 liver respectively. The tone of the preparation was raised by the presence of noradrenaline in the perfusate (concentration: 10(-5) M). 3. Dose-response curves for adenosine and its analogues 5'-N-ethyl-carboxamido-adenosine (NECA), the 2-substituted NECA analogue CGS 21680C, and R- and S-N6-phenyl-isopropyl-adenosine (R- and S-PIA) were obtained after their injection into the hepatic arterial supply. 4. The order of vasodilator potency of these agents was: NECA greater than CGS 21680C greater than adenosine greater than R-PIA greater than S-PIA. Their potency, expressed relative to that of adenosine, was in the approximate ratio 10:3:1:0.3:0.1, consistent with that resulting from activation of P1-purinoceptors of the A2 sub-type (which mediate vasodilatation due to adenosine). 5. The P1-purinoceptor antagonist 8-phenyltheophylline (10(-5) M) caused significant attenuation of the vasodilatation to adenosine and analogues. 6. It is concluded that adenosine-induced dilatation of the hepatic arterial vascular bed is mediated by P1-purinoceptors of the A2 sub-type. | lld:pubmed |
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| pubmed-article:1878748 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1878748 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1878748 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1878748 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1878748 | pubmed:month | May | lld:pubmed |
| pubmed-article:1878748 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:1878748 | pubmed:author | pubmed-author:BurnstockGG | lld:pubmed |
| pubmed-article:1878748 | pubmed:author | pubmed-author:AlexanderBB | lld:pubmed |
| pubmed-article:1878748 | pubmed:author | pubmed-author:MathieR TRT | lld:pubmed |
| pubmed-article:1878748 | pubmed:author | pubmed-author:RalevicVV | lld:pubmed |
| pubmed-article:1878748 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1878748 | pubmed:volume | 103 | lld:pubmed |
| pubmed-article:1878748 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1878748 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1878748 | pubmed:pagination | 1103-7 | lld:pubmed |
| pubmed-article:1878748 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:1878748 | pubmed:meshHeading | pubmed-meshheading:1878748-... | lld:pubmed |
| pubmed-article:1878748 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1878748 | pubmed:articleTitle | Adenosine-induced dilatation of the rabbit hepatic arterial bed is mediated by A2-purinoceptors. | lld:pubmed |
| pubmed-article:1878748 | pubmed:affiliation | Department of Surgery, Royal Postgraduate Medical School, London. | lld:pubmed |
| pubmed-article:1878748 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1878748 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:1878748 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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