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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1991-9-27
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pubmed:abstractText |
1. This study was carried out in order to identify the receptor responsible for adenosine-induced dilatation of the hepatic arterial vascular bed. 2. Livers of 10 New Zealand White rabbits were perfused in vitro with Krebs-Bülbring buffer via the hepatic artery and the portal vein at constant flows of 26 and 77 ml min-1 100 g-1 liver respectively. The tone of the preparation was raised by the presence of noradrenaline in the perfusate (concentration: 10(-5) M). 3. Dose-response curves for adenosine and its analogues 5'-N-ethyl-carboxamido-adenosine (NECA), the 2-substituted NECA analogue CGS 21680C, and R- and S-N6-phenyl-isopropyl-adenosine (R- and S-PIA) were obtained after their injection into the hepatic arterial supply. 4. The order of vasodilator potency of these agents was: NECA greater than CGS 21680C greater than adenosine greater than R-PIA greater than S-PIA. Their potency, expressed relative to that of adenosine, was in the approximate ratio 10:3:1:0.3:0.1, consistent with that resulting from activation of P1-purinoceptors of the A2 sub-type (which mediate vasodilatation due to adenosine). 5. The P1-purinoceptor antagonist 8-phenyltheophylline (10(-5) M) caused significant attenuation of the vasodilatation to adenosine and analogues. 6. It is concluded that adenosine-induced dilatation of the hepatic arterial vascular bed is mediated by P1-purinoceptors of the A2 sub-type.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1878748-1697200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1878748-1715228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1878748-1972898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1878748-2579585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1878748-2652149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1878748-2795461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1878748-2795469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1878748-2829826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1878748-2849674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1878748-2981319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1878748-3004232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1878748-3010074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1878748-3012086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1878748-3017353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1878748-3555319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1878748-3656113,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1878748-3683077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1878748-3904482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1878748-4042009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1878748-6100842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1878748-6287298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1878748-6313897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1878748-6329779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1878748-6641949
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-(4-(2-carboxyethyl)phenethylamino)...,
http://linkedlifedata.com/resource/pubmed/chemical/8-phenyltheophylline,
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine-5'-(N-ethylcarboxamide),
http://linkedlifedata.com/resource/pubmed/chemical/Antihypertensive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Phenethylamines,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylisopropyladenosine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic,
http://linkedlifedata.com/resource/pubmed/chemical/Theophylline
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1103-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:1878748-Acetylcholine,
pubmed-meshheading:1878748-Adenosine,
pubmed-meshheading:1878748-Adenosine-5'-(N-ethylcarboxamide),
pubmed-meshheading:1878748-Animals,
pubmed-meshheading:1878748-Antihypertensive Agents,
pubmed-meshheading:1878748-Female,
pubmed-meshheading:1878748-Hepatic Artery,
pubmed-meshheading:1878748-Liver Circulation,
pubmed-meshheading:1878748-Male,
pubmed-meshheading:1878748-Phenethylamines,
pubmed-meshheading:1878748-Phenylisopropyladenosine,
pubmed-meshheading:1878748-Portal Vein,
pubmed-meshheading:1878748-Rabbits,
pubmed-meshheading:1878748-Receptors, Purinergic,
pubmed-meshheading:1878748-Theophylline,
pubmed-meshheading:1878748-Vasodilation
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pubmed:year |
1991
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pubmed:articleTitle |
Adenosine-induced dilatation of the rabbit hepatic arterial bed is mediated by A2-purinoceptors.
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pubmed:affiliation |
Department of Surgery, Royal Postgraduate Medical School, London.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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