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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1991-9-30
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pubmed:abstractText |
Two hundred and fifty evaluable patients with breast cancer entered a protocol combining neoadjuvant and consolidation therapy by vinblastine (V), thiotepa (T), methotrexate (m) and 5-fluorouracil (f) (VTMF) with or without Adriamycin (A) (Doxorubicin; Adria Laboratories, Colombus, OH USA), and radiation therapy as exclusive locoregional treatment. Tamoxifen was given to 195 patients, 130 post menopausal and 65 pre-menopausal, and was omitted in 55 patients (31 postmenopausal and 24 pre-menopausal). There were 19 stage I, 86 IIa, 51 IIB, 36 IIIA and 58 IIIB. Primary chemotherapy induced tumor volume regression of more than 75% in 41% of the patients and complete clinical regression in 30% of the patients. The 5 years DFS rates were 100% for stage I, 82% for stage IIA, 61% for stage IIB, 46% for stage IIIA and 52% for stage IIIB patients. Among the 72 primary relapses there were 39 distant metastases, 6 locoregional and distant metastasis and 27 isolated locoregional metastases. The actuarial rate of locoregional recurrence is 13% for T2, 18% for T3, 19% for T4. At 5 years the rate of breast preservation was 94%. Cosmetic results are excellent or good for most patients. The 5 years overall survival (OS) were 95% for stage I, 94% for stage IA, 80% for stage IIB, 60% for stage IIIA and 58% for stage IIIB. In multivariate analysis tumor regression appears as an independent and significant factor. This parameter should be preserved in many patients with infiltrative breast cancer.
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pubmed:language |
fre
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0007-4551
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
435-43
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pubmed:dateRevised |
2009-11-11
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pubmed:meshHeading |
pubmed-meshheading:1878605-Actuarial Analysis,
pubmed-meshheading:1878605-Adult,
pubmed-meshheading:1878605-Aged,
pubmed-meshheading:1878605-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:1878605-Breast Neoplasms,
pubmed-meshheading:1878605-Combined Modality Therapy,
pubmed-meshheading:1878605-Female,
pubmed-meshheading:1878605-Humans,
pubmed-meshheading:1878605-Middle Aged,
pubmed-meshheading:1878605-Neoplasm Recurrence, Local,
pubmed-meshheading:1878605-Neoplasm Staging,
pubmed-meshheading:1878605-Prognosis,
pubmed-meshheading:1878605-Survival Rate,
pubmed-meshheading:1878605-Tamoxifen
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pubmed:year |
1991
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pubmed:articleTitle |
[Tumor regression as a prognostic factor in breast cancer].
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pubmed:affiliation |
Service d'oncologie médicale, hôpital de la Salpêtrière, Paris, France.
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pubmed:publicationType |
Journal Article,
English Abstract
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