Source:http://linkedlifedata.com/resource/pubmed/id/18785113
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
2008-9-11
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| pubmed:abstractText |
To study a-Methylacyl coenzyme A racemase (AMACR) expression in gastric intestinal-type adenocarcinoma and its precursors, we performed an immunohistochemical assay (using an avidin-biotin-peroxidase complex method) on 106 paraffin-embedded gastric mucosal biopsy samples and 25 gastrectomy samples (37 negative for dysplasia; 30 indefinite for dysplasia; 22 low-grade dysplasia; 25 high-grade dysplasia; and 34 invasive intestinal adenocarcinoma). The results showed that AMACR staining was uniformly negative in the groups negative for dysplasia and indefinite for dysplasia. Only 1 of 22 (4.5%) low-grade dysplasia showed weak staining for AMACR. In the groups of high-grade dysplasia and invasive intestinal-type adenocarcinoma, however, 19 of 25 (76%) and 18 of 34 (52.9%) were positive for AMACR respectively. Expression of AMACR was not correlated with location, H. Pylori infection or intestinal metaplasia. These results suggested that AMACR may play a role in the intermediate stage of gastric carcinogenesis. The high level expression of AMACR in high-grade dysplasia and carcinoma suggests that it may be a useful biomarker in distinguishing high-grade dysplasia and carcinoma from low-grade dysplasia.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
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| pubmed:issn |
1699-5848
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
23
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1315-20
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| pubmed:meshHeading |
pubmed-meshheading:18785113-Adenocarcinoma,
pubmed-meshheading:18785113-Adult,
pubmed-meshheading:18785113-Aged,
pubmed-meshheading:18785113-Aged, 80 and over,
pubmed-meshheading:18785113-Cell Differentiation,
pubmed-meshheading:18785113-Cell Transformation, Neoplastic,
pubmed-meshheading:18785113-Female,
pubmed-meshheading:18785113-Gastric Mucosa,
pubmed-meshheading:18785113-Helicobacter pylori,
pubmed-meshheading:18785113-Humans,
pubmed-meshheading:18785113-Immunohistochemistry,
pubmed-meshheading:18785113-Male,
pubmed-meshheading:18785113-Metaplasia,
pubmed-meshheading:18785113-Middle Aged,
pubmed-meshheading:18785113-Neoplasm Staging,
pubmed-meshheading:18785113-Precancerous Conditions,
pubmed-meshheading:18785113-Racemases and Epimerases,
pubmed-meshheading:18785113-Stomach Neoplasms,
pubmed-meshheading:18785113-Tumor Markers, Biological
|
| pubmed:year |
2008
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| pubmed:articleTitle |
a-Methylacyl coenzyme A racemase is highly expressed in the intestinal-type adenocarcinoma and high-grade dysplasia lesions of the stomach.
|
| pubmed:affiliation |
Department of Pathology, Nanjing Medical College Affiliated Nanjing First Hospital, Nanjing Jiangsu, P. R. China. huangwb908@hotmail.com
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| pubmed:publicationType |
Journal Article
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