Source:http://linkedlifedata.com/resource/pubmed/id/18782050
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2008-9-10
|
| pubmed:abstractText |
Alzheimer's disease is a complex neurodegenerative disorder with a multifaceted pathogenesis. This fact has long halted the development of effective anti-Alzheimer drugs. Recently, however, basis for a therapeutic strategy based on multi-target-directed ligands has been formed. In this context, dual binding site acetylcholinesterase inhibitors represent a suitable starting point. The rational modification of their structures to provide them with additional biological properties has emerged as a successful approach.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
1389-5575
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
960-7
|
| pubmed:meshHeading |
pubmed-meshheading:18782050-Alzheimer Disease,
pubmed-meshheading:18782050-Binding Sites,
pubmed-meshheading:18782050-Cholinesterase Inhibitors,
pubmed-meshheading:18782050-Drug Delivery Systems,
pubmed-meshheading:18782050-Humans,
pubmed-meshheading:18782050-Ligands,
pubmed-meshheading:18782050-Molecular Structure,
pubmed-meshheading:18782050-Polyamines,
pubmed-meshheading:18782050-Structure-Activity Relationship
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
From dual binding site acetylcholinesterase inhibitors to multi-target-directed ligands (MTDLs): a step forward in the treatment of Alzheimer's disease.
|
| pubmed:affiliation |
Department of Pharmaceutical Sciences, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy. marialaura.bolognesi@unibo.it
|
| pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
|