Linked Life Data

18781471

Source:http://linkedlifedata.com/resource/pubmed/id/18781471

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2008-9-10
pubmed:abstractText
Myocardial dilatation and dysfunction in the absence of significant coronary heart disease has been termed "idiopathic" dilated cardiomyopathy (iDCM), which--according to the 1995 task force report on the classification of cardiomyopathies-besides genetic, toxic or infectious causes also includes immune-mediated heart muscle damage in the spectrum of putative DCM etiologies. Incremental research on this topic particularly in the past few years has significantly contributed evidence to the hypothesis that autoimmune reactions against certain myocyte antigens may play a pivotal role in the initiation and/or progression of DCM. Recent transfer experiments in animals (mostly rodents) performed by various groups throughout the world and some preliminary clinical data even indicate that a few of these autoantibodies are indeed "pathogenic", inferring that they can actually cause cardiac dysfunction and heart failure by their own. Dependent on the individual genetic predisposition such harmful autoimmune reactions are supposed to emerge as a consequence of heart muscle damage induced by viral triggers, ischemia or exposure to cardiotoxins leading to myocyte apoptosis (and/or necrosis) and subsequent liberation of a "critical amount" of self-antigens previously hidden to the immune system. The following article will summarize the so far available evidence for an implication of a confined number of harmful autoantibodies directed against specific cardiac antigens in the pathogenesis of DCM.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1607-842X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
454-61
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Pathological autoantibodies in cardiomyopathy.
pubmed:affiliation
Department of Internal Medicine, Medizinische Klinik und Poliklinik I, Cardiology, University of Würzburg, Würzburg, Germany.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't