Source:http://linkedlifedata.com/resource/pubmed/id/18781446
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
2008-11-10
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pubmed:abstractText |
The results of the present study show that the early inflammatory response in plasminogen (plg)-deficient mice is not altered compared to that in wild-type (wt) mice. Therefore the chronicity of the perforation in the long-term healing experiment cannot be explained by an impairment of the early inflammatory response, but rather by an impairment in activation of the inflammatory cells. These findings give further insight into the mechanisms resulting in a clinically seen chronic tympanic membrane (TM) perforation and thus possible therapeutic strategies to replace today's conventional surgical treatment of these perforations.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
1651-2251
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
128
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1294-302
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pubmed:meshHeading |
pubmed-meshheading:18781446-Animals,
pubmed-meshheading:18781446-Genotype,
pubmed-meshheading:18781446-Inflammation,
pubmed-meshheading:18781446-Lymphocytes,
pubmed-meshheading:18781446-Macrophages,
pubmed-meshheading:18781446-Male,
pubmed-meshheading:18781446-Mice,
pubmed-meshheading:18781446-Mice, Inbred C57BL,
pubmed-meshheading:18781446-Mice, Inbred DBA,
pubmed-meshheading:18781446-Microscopy,
pubmed-meshheading:18781446-Neutrophil Infiltration,
pubmed-meshheading:18781446-Neutrophils,
pubmed-meshheading:18781446-Plasminogen,
pubmed-meshheading:18781446-Tympanic Membrane,
pubmed-meshheading:18781446-Tympanic Membrane Perforation
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pubmed:year |
2008
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pubmed:articleTitle |
Lack of plasminogen does not alter the early inflammatory response following a tympanic membrane perforation: a study in plasminogen-deficient mice.
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pubmed:affiliation |
Department of Clinical Sciences, Otorhinolaryngology, Umeå University, Umeå, Sweden. annika.hansson@ent.umu.se
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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