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rdf:type |
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lifeskim:mentions |
umls-concept:C0008546,
umls-concept:C0018270,
umls-concept:C0034786,
umls-concept:C0271510,
umls-concept:C0334227,
umls-concept:C0376358,
umls-concept:C0439590,
umls-concept:C1334537,
umls-concept:C1708715,
umls-concept:C1880177,
umls-concept:C2346689
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pubmed:issue |
16
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pubmed:dateCreated |
2008-11-3
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pubmed:abstractText |
Growth of most ablation-resistant prostate cancers (CaPs) is dependent on androgen receptor (AR) activity in chromatin, but cancer cells in these tumors have acquired altered AR activation. It is unclear how the aberrantly activated AR loads onto regulatory regions of AR-targeted genes. The purpose of this study was to assess the AR chromatin loading in an androgen-depleted environment.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Androgens,
http://linkedlifedata.com/resource/pubmed/chemical/Anilides,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Chromatin,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Acetyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/NCOA1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/NCOA2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nitriles,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Coactivator 1,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Coactivator 2,
http://linkedlifedata.com/resource/pubmed/chemical/Prostate-Specific Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/ROCK1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Androgen,
http://linkedlifedata.com/resource/pubmed/chemical/Tosyl Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/bicalutamide,
http://linkedlifedata.com/resource/pubmed/chemical/rho-Associated Kinases
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1097-0045
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1816-26
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18780293-Adenocarcinoma,
pubmed-meshheading:18780293-Androgens,
pubmed-meshheading:18780293-Anilides,
pubmed-meshheading:18780293-Antineoplastic Agents,
pubmed-meshheading:18780293-Cell Line, Tumor,
pubmed-meshheading:18780293-Cell Proliferation,
pubmed-meshheading:18780293-Chromatin,
pubmed-meshheading:18780293-DNA, Neoplasm,
pubmed-meshheading:18780293-Histone Acetyltransferases,
pubmed-meshheading:18780293-Humans,
pubmed-meshheading:18780293-Male,
pubmed-meshheading:18780293-Nitriles,
pubmed-meshheading:18780293-Nuclear Receptor Coactivator 1,
pubmed-meshheading:18780293-Nuclear Receptor Coactivator 2,
pubmed-meshheading:18780293-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:18780293-Prostate-Specific Antigen,
pubmed-meshheading:18780293-Prostatic Neoplasms,
pubmed-meshheading:18780293-Protein Binding,
pubmed-meshheading:18780293-Receptors, Androgen,
pubmed-meshheading:18780293-Tosyl Compounds,
pubmed-meshheading:18780293-Transcription Factors,
pubmed-meshheading:18780293-rho-Associated Kinases
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pubmed:year |
2008
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pubmed:articleTitle |
Prolonged androgen receptor loading onto chromatin and the efficient recruitment of p160 coactivators contribute to androgen-independent growth of prostate cancer cells.
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pubmed:affiliation |
Department of Urology, University of California, Davis, School of Medicine, Sacramento, California 95817, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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