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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2008-9-23
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pubmed:abstractText |
A novel series of benzo[a]carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor is reported. Starting from a 3.4 microM high throughput screen hit, members of this series have been identified which are full agonists with functional potency <50 nM and oral bioavailability in mice.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:AlperPhil BPB,
pubmed-author:ChangJonathanJ,
pubmed-author:ChatterjeeArnabA,
pubmed-author:ChowDonaldD,
pubmed-author:GerkenAndreaA,
pubmed-author:GordonPerryP,
pubmed-author:HeYunY,
pubmed-author:KaranewskyDonald SDS,
pubmed-author:LaoJianminJ,
pubmed-author:LuWenshuoW,
pubmed-author:MarsiljeThomas HTH,
pubmed-author:MutnickDanielD,
pubmed-author:RobertsMichael JMJ,
pubmed-author:SeidelH MartinHM,
pubmed-author:TianShin-ShaySS,
pubmed-author:TuntlandToveT,
pubmed-author:XuN ZNZ
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5255-8
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pubmed:meshHeading |
pubmed-meshheading:18778936-Administration, Oral,
pubmed-meshheading:18778936-Animals,
pubmed-meshheading:18778936-Benzene Derivatives,
pubmed-meshheading:18778936-Carbazoles,
pubmed-meshheading:18778936-Combinatorial Chemistry Techniques,
pubmed-meshheading:18778936-Drug Design,
pubmed-meshheading:18778936-Humans,
pubmed-meshheading:18778936-Mice,
pubmed-meshheading:18778936-Molecular Structure,
pubmed-meshheading:18778936-Nuclear Magnetic Resonance, Biomolecular,
pubmed-meshheading:18778936-Receptors, Thrombopoietin,
pubmed-meshheading:18778936-Structure-Activity Relationship,
pubmed-meshheading:18778936-Thrombopoietin
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pubmed:year |
2008
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pubmed:articleTitle |
Discovery and biological evaluation of benzo[a]carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor.
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pubmed:affiliation |
Genomics Institute of the Novartis Research Foundation (GNF), San Diego, CA 92121, USA.
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pubmed:publicationType |
Journal Article
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